Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy
Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy
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DOI：
10.1016/s0360-3016(98)00544-6
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发表时间：
1999-04-01
影响因子：
7
通讯作者：
Kawachi, K
中科院分区：
文献类型：
--
作者：
Kanai, T;Endo, M;Kawachi, K
目的：研究重离子放射治疗的照射系统和生物物理特性。方法和材料：研制了一种用于重离子放射治疗的照射系统。摆动磁铁和散射体被用来平坦辐射场。照射系统中还安装了使用X射线和图像增强器的患者定位系统。根据单能束的生物物理特性，对碳束的深度-剂量分布进行了修正，形成了扩展的Bragg峰。建立重离子放射治疗剂量学系统，按照治疗计划安全地给患者输送重离子剂量。美国国家放射科学研究院(NIRS)回旋加速器用30 MeV的重离子束轰击铍靶产生的中子束，在扩展的Bragg峰中，发现80keV/亩的碳束与中子束的生物响应相当。结果：从1994年6月开始，采用290、350和400 MeV/u的碳束进行临床试验。截至1997年底，已有300多名患者接受了这一照射系统的治疗。(C)1999年爱思唯尔科学公司。
Purpose: The irradiation system and biophysical characteristic carbon beams are examined regarding radiation therapy.Methods and Materials: An irradiation system was developed for heavy-ion radiotherapy. Wobbler magnets and a scatterer were used for flattening the radiation field. A patient-positioning system using X ray and image intensifiers was also installed in the irradiation system. The depth-dose distributions of the carbon beams were modified to make a spread-out Bragg peak, which was designed based on the biophysical characteristics of monoenergetic beams. A dosimetry system for heavy-ion radiotherapy was established to deliver heavy-ion doses safely to the patients according to the treatment planning. A carbon beam of 80 keV/mu m in the spread-out Bragg peak was found to be equivalent in biological responses to the neutron beam that is produced at cyclotron facility in National Institute Radiological Sciences (NIRS) by bombarding 30-MeV deuteron beam on beryllium target. The fractionation schedule of the NIRS neutron therapy was adapted for the first clinical trials using carbon beams.Results: Carbon beams, 290, 350, and 400 MeV/u, were used for a clinical trial from June of 1994. Over 300 patients have already been treated by this irradiation system by the end of 1997. (C) 1999 Elsevier Science Inc.