Towards component-based validation of GATE: Aspects of the coincidence processor
Towards component-based validation of GATE: Aspects of the coincidence processor
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DOI：
10.1016/j.ejmp.2014.09.001
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发表时间：
2015-02-01
影响因子：
3.4
通讯作者：
Badawi, Ramsey D.
中科院分区：
文献类型：
--
作者：
Moraes, Eder R.;Poon, Jonathan K.;Badawi, Ramsey D.
GATE是广泛用于发射层析成像蒙特卡罗模拟的公共领域软件。GATE的验证主要是在整个系统的基础上进行的，留下了一个子系统中的错误可能被其他子系统中的错误所抵消的可能性。我们孤立地评估GATE PET符合生成子系统的准确性，重点关注最接近模拟大多数商用扫描仪的选项。独立的符合生成器由东芝医学研究单位(TMRU)和加州大学戴维斯分校的团队编写。在GATE中创建了一个类似西门子MCT扫描仪的型号。记录了与探测器相互作用的湮没光子。使用GATE、TMRU和UC Davis程序产生重合，并将结果与从光子相互作用历史获得的“地面真相”进行比较。对GATE进行了两次测试，一次是每个合格的单一事件打开一个时间窗口并启动符合检查(“多窗口方法”)，另一次是打开一个时间窗口并仅由前一个时间窗口结束后发生的第一个单一事件启动符合检查(“单窗口方法”)。比较了真实的、分散的和随机的巧合。TMRU和UC Davis符合产生器与地面实况符合得很好。对于GATE，如果选择单窗口方法选项，并且在不使用延迟重合选项的情况下估计随机重合，则可以获得合理的精度。然而，在此门版本中，其他参数组合可能会导致重大误差。(C)2014年意大利菲西卡医学协会。爱思唯尔有限公司出版。保留所有权利。
GATE is public domain software widely used for Monte Carlo simulation in emission tomography. Validations of GATE have primarily been performed on a whole-system basis, leaving the possibility that errors in one sub-system may be offset by errors in others. We assess the accuracy of the GATE PET coincidence generation sub-system in isolation, focusing on the options most closely modeling the majority of commercially available scanners.Independent coincidence generators were coded by teams at Toshiba Medical Research Unit (TMRU) and UC Davis. A model similar to the Siemens mCT scanner was created in GATE. Annihilation photons interacting with the detectors were recorded. Coincidences were generated using GATE, TMRU and UC Davis code and results compared to "ground truth" obtained from the history of the photon interactions. GATE was tested twice, once with every qualified single event opening a time window and initiating a coincidence check (the "multiple window method"), and once where a time window is opened and a coincidence check initiated only by the first single event to occur after the end of the prior time window (the "single window method"). True, scattered and random coincidences were compared. Noise equivalent count rates were also computed and compared.The TMRU and UC Davis coincidence generators agree well with ground truth. With GATE, reasonable accuracy can be obtained if the single window method option is chosen and random coincidences are estimated without use of the delayed coincidence option. However in this GATE version, other parameter combinations can result in significant errors. (C) 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.