Nucleic acid-triggered fluorescent probe activation by the staudinger reaction
Nucleic acid-triggered fluorescent probe activation by the staudinger reaction
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DOI：
10.1021/ja0452626
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发表时间：
2004-12-22
影响因子：
15
通讯作者：
Taylor, JS
中科院分区：
文献类型：
--
作者：
Cai, JF;Li, XX;Taylor, JS
体内DNA或RNA的高度序列特异性和灵敏度检测系统将在生物学和医学中用于监测基因表达和诊断病变细胞。在此，我们描述了一种新的核酸触发的荧光探针系统，该系统由生物相容性和化学选择性施陶丁格反应激活。
Highly sequence specific and sensitive detection systems for DNA or RNA in vivo would be of great use in biology and medicine for monitoring gene expression and diagnosing diseased cells. Herein we describe a new nucleic acid-triggered fluorescent probe system that is activated by a biocompatible and chemoselective Staudinger reaction.