Multicopy blaOXA-58 gene as a source of high-Level resistance to carbapenems in Acinetobacter baumannii
Multicopy blaOXA-58 gene as a source of high-Level resistance to carbapenems in Acinetobacter baumannii
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DOI：
10.1128/aac.01502-06
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发表时间：
2007-07-01
影响因子：
4.9
通讯作者：
Carattoli, Alessandra
中科院分区：
文献类型：
--
作者：
Bertini, Alessia;Poirel, Laurent;Carattoli, Alessandra
研究了2005年在意大利罗马一家大型大学医院收集的鲍曼不动杆菌分离株中观察到的碳青霉烯类抗生素异质性耐药水平的起源机制。这些分离株是相关的，具有携带碳青霉烯类水解苯唑西林酶基因bla（OXA-58）的相似质粒，但对碳青霉烯类的耐药性水平不同。bla（OXA-58）基因周围序列的分析显示遗传变异性，在几个分离株中存在bla（OXA-58）基因的多个拷贝;该额外拷贝数可能与IS 26介导的转座或重组过程相关。
The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla(OXA-58) but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the bla(OXA-58) gene showed genetic variability, with the presence in several isolates of multiple copies of the bla(OXA-58) gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process.