Non-inhibition of acetylcholinesterase by cycloSal nucleotides
Non-inhibition of acetylcholinesterase by cycloSal nucleotides
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DOI：
10.1081/ncn-120022667
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发表时间：
2003-01-01
影响因子：
1.3
通讯作者：
Meier, C
中科院分区：
文献类型：
--
作者：
Ducho, C;Balzarini, J;Meier, C
建立了一种基于Rappaport法的乙酰胆碱酯酶（AChE）测定方法，以研究几种环Sal核苷酸对电刺激和人源（纯化酶）AChE的作用。乙酰胆碱酯酶是一种生理必需的酶，因为它催化神经递质乙酰胆碱的水解。在任何情况下均未观察到抑制。
An acetylcholinesterase (AChE) assay based oil the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. No inhibition was observed in any of the cases.