Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
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DOI：
10.1038/nm1529
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发表时间：
2007-02-01
期刊：
影响因子：
82.9
通讯作者：
Peiris, J. S. M.
中科院分区：
文献类型：
--
作者：
Nicholls, J. M.;Chan, M. C. W.;Peiris, J. S. M.
甲型H5N1流感病毒很少在人与人之间传播是由于人类上呼吸道上皮中推测的唾液酸α - 2-3病毒受体缺乏，因此推测病毒无法在该部位有效复制。我们现在证明，尽管明显缺乏这些受体，但人鼻咽、腺样体和扁桃体组织的离体培养物仍可感染H5N1病毒。
Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid alpha 2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.