Controlling the receptor for advanced glycation end-products to conquer diabetic vascular complications.
Controlling the receptor for advanced glycation end-products to conquer diabetic vascular complications.
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DOI：
10.1111/j.2040-1124.2011.00191.x
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发表时间：
2012-03-28
影响因子：
3.2
通讯作者：
Yamamoto H
中科院分区：
文献类型：
--
作者：
Yamamoto Y;Yamamoto H
糖尿病血管并发症，如心血管疾病、中风和微血管病，导致长期糖尿病患者的发病率和死亡率很高。晚期糖基化终产物（AGE）在细胞内和细胞外的广泛形成被认为是糖尿病血管损伤的一个致病因素。受体依赖性机制参与AGE诱导的细胞功能障碍和组织损伤。AGE受体（RAGE）最初是一种AGE结合受体，现在被认为是模式识别受体的成员，也是一种介导身体危险信号的促炎分子装置。先前的动物研究表明糖尿病血管损伤依赖于胰岛素。针对糖尿病血管并发症的预防和治疗策略将对糖尿病血管并发症的防治具有重要意义。（J Diabetes Invest，doi：10.1111/j.2040 - 1124.2011.00191.x，2012）
Diabetic vascular complications, such as cardiovascular disease, stroke and microangiopathy, lead to high rates of morbidity and mortality in patients with long‐term diabetes. Extensive intracellular and extracellular formation of advanced glycation end‐products (AGE) is considered a causative factor in vascular injuries in diabetes. Receptor‐dependent mechanisms are involved in AGE‐induced cellular dysfunction and tissue damage. The receptor for AGE (RAGE), originally an AGE‐binding receptor, is now recognized as a member of pattern‐recognition receptors and a pro‐inflammatory molecular device that mediates danger signals to the body. Previous animal studies have shown RAGE dependent of diabetic vascular injuries. Prophylactic and therapeutic strategies focusing on RAGE and its ligand axis will be of great importance in conquering diabetic vascular complications. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00191.x, 2012)
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