Behavioural recovery after unilateral lesion of the dopaminergic mesotelencephalic pathway: Effect of repeated testing
Behavioural recovery after unilateral lesion of the dopaminergic mesotelencephalic pathway: Effect of repeated testing
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DOI：
10.1016/s0306-4522(97)00498-3
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发表时间：
1998-05-01
期刊：
影响因子：
3.3
通讯作者：
Barneoud, P
中科院分区：
文献类型：
--
作者：
Abrous, DN;Rodriguez, JJ;Barneoud, P
研究了成年大鼠黑质纹状体通路完全单侧损伤后的功能恢复。我们研究了训练对损伤后自发或诱导的姿势偏差的影响。测量偏侧化的两个任务用于评估病变引起的姿势偏差：在Y-迷宫中评估自发不对称性，而通过悬挂大鼠的尾巴来测量诱导的身体偏差。在损伤后的三个不同时间评估恢复情况。评价成年大鼠损伤的短期、中期和长期效应，并与多巴胺能移植的效应进行比较。在成年损伤大鼠，破坏多巴胺能神经支配的新纹状体诱导最初的同侧偏置测量的“尾巴挂测试”和Y-迷宫。在尾悬挂试验中观察到功能恢复，因为重复试验时同侧偏倚下降。除此之外，还有一个损伤后的间隔效应，因为在长期损伤的大鼠中重复测试时，姿势偏差消失得更快。这种自发性恢复受到纹状体内多巴胺能移植物的损害。此外，在Y-迷宫测试中未观察到自发恢复。这些观察结果表明，重复测试可以影响黑质纹状体多巴胺系统受损的长期影响。(C)1998年IBRO。出版社：Elsevier Science Ltd
Functional recovery following a complete unilateral lesion of the nigostriatal pathway in adult rats was studied. We examined the effect of training on the spontaneous or induced postural bias following the lesion. Two tasks measuring lateralization were used to assess the lesion-induced postural bias: spontaneous asymmetry was evaluated in the Y-maze, whereas induced body bias was measured by hanging the rat by its tail. Recovery was assessed at three different times following the lesion. The effects of lesion in adult rats in the short, medium and long term were evaluated and compared with the effects of dopaminergic transplants. In adult lesioned rats, destruction of dopaminergic innervation of the neostriatum induced initially an ipsilateral bias as measured in the "tail hang test" and the Y-maze. Recovery of function was observed in the tail hang test as ipsilateral bias declined on repeated testing. Apart from this effect, there was a post-lesion interval effect, since the postural bias disappeared more rapidly on repeated testing in the long-term lesioned rats. This spontaneous recovery was impaired by intrastriatal dopaminergic grafts. Furthermore, no spontaneous recovery was observed in the Y-maze test. These observations show that repeated testing can influence the long-term effects of damage to the nigrostriatal dopamine system. (C) 1998 IBRO. Published by Elsevier Science Ltd.