An efficient approach to construct benzisothiazol-3(2H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide.
An efficient approach to construct benzisothiazol-3(2H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide.
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DOI：
10.1039/c6ob00819d
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发表时间：
2016-06
影响因子：
3.2
通讯作者：
Ting Li;Lei Yang;Kaidong Ni;Zhenyu Shi;Fei Li;Dongyin Chen
中科院分区：
文献类型：
--
作者：
Ting Li;Lei Yang;Kaidong Ni;Zhenyu Shi;Fei Li;Dongyin Chen
以易得的2-卤代苯甲酰胺和二硫化碳为原料，在铜催化下合成了苯异噻唑-3(2H)-酮，25例以30-%的产率得到了相应的目标产物。反应通过S-C键和S-N键形成的连续过程进行。
An efficient copper-catalyzed reaction for the synthesis of benzisothiazol-3(2H)-ones has been developed, starting from easily available 2-halobenzamides and carbon disulfide, which gave the corresponding target products in 30-89% yield for 25 examples. The reaction proceeds via a consecutive process with S-C bond and S-N bond formation.