Variation with temperature of the solubilities of inhaled anaesthetics in water, oil and biological media.
Variation with temperature of the solubilities of inhaled anaesthetics in water, oil and biological media.
复制标题
吸入麻醉剂在水、油和生物介质中的溶解度随温度的变化。
DOI：
10.1093/bja/45.3.294
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发表时间：
1973
影响因子：
9.8
通讯作者：
W. Mapleson
中科院分区：
文献类型：
--
作者：
P. Allott;A. Steward;V. Flook;W. Mapleson
方法根据已公布的溶解度系数计算溶解度温度系数。必要时，根据需要将公布的系数转换为Ostwald或Bunsen系数（Steward et al., 1973）（附录）。为了保持合理的精度，并将结果与生物温度联系起来，只有在满足以下条件时才计算温度系数：单个研究者在不低于10℃和包括37℃的两个或两个以上温度范围内测量一种剂在物质或组织中的溶解度。在0至45℃范围内两个最广泛分离温度的溶解度系数用于根据附录中给出的方法计算温度系数。超过50篇论文（在参考文献列表中标有星号）提供了满足这些标准的数据，并得出了近200个温度系数。在12个例子中，对于给定的试剂和溶剂，对来自单一论文的所有数据进行了回归线拟合；但这与仅使用最高和最低温度的溶解度的简单程序得出的结果非常相似。因此，这个简单的程序被常规使用。
METHODTemperature coefficients of solubility were calculated from published solubility coefficients at different temperatures. Where necessary, published coefficients were converted to Ostwald or Bunsen coefficients (Steward et al., 1973) as required (Appendix). In order to maintain a reasonable degree of accuracy, and to relate the results to biological temperatures, temperature coefficients were calculated only when the following criteria were satisfied: a single investigator measured the solubility of an agent in a substance or tissue at two or more temperatures over a range of not less than 10 C and including 37 C. The solubility coefficients for the two most widely separated temperatures in the range 0 to 45 C were used to calculate the temperature coefficient according to the methods given in the Appendix. Over 50 papers (marked with an asterisk in the list of references) provided data which satisfied these criteria and yielded nearly 200 temperature coefficients. In 12 instances a regression line was fitted to all the data from a single paper for a given agent and solvent; but this gave closely similar results to the simple procedure of using only the solubilities for the highest and lowest temperatures. The simple procedure was therefore used routinely.