Responses of Prefrontal Multisensory Neurons to Mismatching Faces and Vocalizations
Responses of Prefrontal Multisensory Neurons to Mismatching Faces and Vocalizations
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DOI：
10.1523/jneurosci.5168-13.2014
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发表时间：
2014-08-20
影响因子：
5.3
通讯作者：
Romanski, Lizabeth M.
中科院分区：
文献类型：
--
作者：
Diehl, Maria M.;Romanski, Lizabeth M.
社会交流依赖于听觉和视觉信息的整合，这些信息存在于面部和发声中。有证据表明，整合来自多个来源的信息增强知觉相比，一个单峰刺激的处理。我们以前的研究表明，单个神经元在腹外侧前额叶皮层（VLPFC）的恒河猴（Macaca mulatta）响应和整合同种发声及其伴随的面部姿态。因此，我们感兴趣的是VLPFC神经元如何对匹配（一致）和不匹配（不一致）的面孔和发声做出不同的反应。我们记录了VLPFC神经元在呈现电影与一致或不一致的物种特异性的面部表情和发声，以及他们的单峰组件。记录显示，虽然许多VLPFC单位是多感官的，并对面孔，发声，或其组合作出反应，一个子集的神经元显示出显着的变化，神经元活动的反应不一致与一致的发声电影。在这些神经元中，我们通常观察到不一致的抑制在早期的刺激期和不一致的增强在晚期的刺激期。不一致反应的VLPFC神经元双峰和非线性多感觉，培养他们的能力，以应对任何形式的面部发声刺激的变化。这些结果表明，腹侧前额叶神经元响应的视听刺激，这是重要的身份处理和多感官通信信息的整合中的任何一种方式的变化。
Social communication relies on the integration of auditory and visual information, which are present in faces and vocalizations. Evidence suggests that the integration of information from multiple sources enhances perception compared with the processing of a unimodal stimulus. Our previous studies demonstrated that single neurons in the ventrolateral prefrontal cortex (VLPFC) of the rhesus monkey (Macaca mulatta) respond to and integrate conspecific vocalizations and their accompanying facial gestures. We were therefore interested in how VLPFC neurons respond differentially to matching (congruent) and mismatching (incongruent) faces and vocalizations. We recorded VLPFC neurons during the presentation of movies with congruent or incongruent species-specific facial gestures and vocalizations as well as their unimodal components. Recordings showed that while many VLPFC units are multisensory and respond to faces, vocalizations, or their combination, a subset of neurons showed a significant change in neuronal activity in response to incongruent versus congruent vocalization movies. Among these neurons, we typically observed incongruent suppression during the early stimulus period and incongruent enhancement during the late stimulus period. Incongruent-responsive VLPFC neurons were both bimodal and nonlinear multisensory, fostering their ability to respond to changes in either modality of a face-vocalization stimulus. These results demonstrate that ventral prefrontal neurons respond to changes in either modality of an audiovisual stimulus, which is important in identity processing and for the integration of multisensory communication information.