An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis
An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis
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DOI：
10.1016/j.neulet.2009.02.048
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发表时间：
2009-05-15
影响因子：
2.5
通讯作者：
Mori, Norio
中科院分区：
文献类型：
--
作者：
Nakamura, Kazuhiko;Sekine, Yoshimoto;Mori, Norio
甲基苯丙胺仍然是日本滥用最广泛的毒品。慢性甲基苯丙胺使用者表现出精神症状，包括甲基苯丙胺精神病。单胺氧化酶A(MAOA)是神经递质降解的主要酶之一。MAO水平的异常与广泛的精神障碍有关。我们研究了MAOA-u可变数目串联重复序列(VNTR)在甲基苯丙胺精神病中是否具有功能性多态，以及这种多态是否与精神病的延长有关。不出所料，持续性和暂时性甲基苯丙胺精神病患者的MAOa-u频率差异有统计学意义(P=0.018，优势比OR=2.76，95%CI：1.18~6.46)。我们的结果表明，男性MAOA-u VNTR的高活性等位基因类别可能与甲基苯丙胺持续病程的易感性有关。我们发现女性之间没有差异。女性甲基苯丙胺精神病的样本量太小，无法进行有意义的分析。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis. As expected, there was a significant difference in the MAOA-u VNTR between males with persistent versus transient methamphetamine psychosis (p = 0.018, odds ratio (OR) = 2.76, 95% CI: 1.18-6.46). Our results suggest that the high-activity allele class of MAOA-u VNTR in males may be involved in susceptibility to a persistent course of methamphetamine psychosis. We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.