Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease
Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease
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DOI：
10.1016/j.parkreldis.2008.02.002
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发表时间：
2009-01-01
影响因子：
4.1
通讯作者：
Hirata, Koichi
中科院分区：
文献类型：
--
作者：
Suzuki, Keisuke;Miyamoto, Masayuki;Hirata, Koichi
帕金森病（PD）患者常伴有抑郁和夜间睡眠障碍。本研究的目的是确定日本PD患者的抑郁症状和夜间障碍之间的相关性。本多中心横断面研究的受试者为188例PD患者和144例年龄匹配的对照者，他们通过帕金森病睡眠量表（PDSS）评估夜间障碍，通过Zung抑郁自评量表（SDS）评估抑郁症状。在122名患者（64.9%）中发现了抑郁症状（SDS评分>= 40）。PD患者的SDS显著高于对照组。逐步回归模型确定PDSS（p < 0.001）和统一帕金森病评定量表I（精神状态）（p = 0.002）是SDS的重要决定因素。逐步回归分析确定项目15（白天嗜睡）（p = 0.002）、项目13（清晨震颤）（p = 0.008）、项目12（夜间肌张力障碍）（p = 0.015）和项目3（睡眠维持失眠）（p = 0.026）为SDS的显著预测因子。我们的研究结果表明，抑郁症患者的抑郁症状与夜间障碍显着相关，白天嗜睡，肌张力障碍，震颤和睡眠碎片是最常见的夜间障碍抑郁症患者。(C)2008爱思唯尔有限公司保留所有权利。
Depression and nocturnal disturbances are frequent in patients with Parkinson's disease (PD). The aim of this study was to determine the correlation between depressive symptoms and nocturnal disturbances in patients with PD in Japan. The subjects of this multi-center cross-sectional study were 188 patients with PD and 144 age-matched controls who were assessed for nocturnal disturbances by the Parkinson's disease sleep scale (PDSS) and for depressive symptoms by Zung Self-Rating Depression Scale (SDS). Depressive symptoms (SDS score of >= 40) were identified in 122 patients (64.9%). The SDS was significantly higher in PD patients than control Subjects. The stepwise regression model identified PDSS (p < 0.001) and Unified Parkinson's Disease Rating Scale I (mental state) (p = 0.002) as significant determinants of SDS. Stepwise regression analysis identified item 15 (daytime sleepiness) (p = 0.002), item 13 (early morning tremor) (p = 0.008), item 12 (nocturnal dystonia) (p = 0.015), and item 3 (sleep maintenance insomnia) (p = 0.026) as significant predictors of SDS. Our results indicated that depressive symptoms in PD correlate significantly with nocturnal disturbances, and that daytime sleepiness, dystonia, tremor and sleep fragmentation are the most common nocturnal disturbances in depressed patients with PD. (C) 2008 Elsevier Ltd. All rights reserved.