Subthalamic Nucleus Activity Influences Sensory and Motor Cortex during Force Transduction
Subthalamic Nucleus Activity Influences Sensory and Motor Cortex during Force Transduction
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DOI：
10.1093/cercor/bhz264
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发表时间：
2020-04-01
期刊：
影响因子：
3.7
通讯作者：
Richardson, R. Mark
中科院分区：
文献类型：
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作者：
Alhourani, Ahmad;Korzeniewska, Anna;Richardson, R. Mark
丘脑底核(STN)被认为参与暂停或交替地参与行为反应的动态测量，这些角色对于理解深部脑刺激(DBS)治疗中的STN功能具有相互矛盾的含义。为了研究事件相关STN活动的性质和丘脑-下丘脑-皮质动力学，我们进行了初级运动和体感皮层脑电描记，同时受试者(n=10)在DBS植入手术中进行握力任务。锁相分析表明，在贝塔和伽马范围内，STN-皮质相干的周期包括了力传递。与事件相关的因果关系测量表明，STNβ和伽马活动不仅在力量产生期间而且在运动开始之前都能预测运动皮质贝塔和伽马活动。这些发现与STN除了参与正在进行的运动的调节外，还参与运动规划的想法是一致的。我们还展示了STN和躯体感觉皮质之间的双向信息流动，在贝塔和伽马范围内的频率，表明STN在躯体感觉整合中的强大参与。事实上，STN和躯体感觉皮质之间的相互作用，而不是STN和运动皮质之间的相互作用，可以预测PD症状的严重程度。因此，STN随时间动态地对感觉运动行为的多个方面做出贡献。
The subthalamic nucleus (STN) is proposed to participate in pausing, or alternately, in dynamic scaling of behavioral responses, roles that have conflicting implications for understanding STN function in the context of deep brain stimulation (DBS) therapy. To examine the nature of event-related STN activity and subthalamic-cortical dynamics, we performed primary motor and somatosensory electrocorticography while subjects (n = 10) performed a grip force task during DBS implantation surgery. Phase-locking analyses demonstrated periods of STN-cortical coherence that bracketed force transduction, in both beta and gamma ranges. Event-related causality measures demonstrated that both STN beta and gamma activity predicted motor cortical beta and gamma activity not only during force generation but also prior to movement onset. These findings are consistent with the idea that the STN participates in motor planning, in addition to the modulation of ongoing movement. We also demonstrated bidirectional information flow between the STN and somatosensory cortex in both beta and gamma range frequencies, suggesting robust STN participation in somatosensory integration. In fact, interactions in beta activity between the STN and somatosensory cortex, and not between STN and motor cortex, predicted PD symptom severity. Thus, the STN contributes to multiple aspects of sensorimotor behavior dynamically across time.