Performance of decellularized xenogeneic tissue in heart valve replacement.
Performance of decellularized xenogeneic tissue in heart valve replacement.
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DOI：
10.1016/j.biomaterials.2005.05.100
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发表时间：
2006
期刊：
影响因子：
14
通讯作者：
U. Stock;K. Schenke-Layland
中科院分区：
文献类型：
--
作者：
U. Stock;K. Schenke-Layland
由于人类瓣膜（同种异体移植物）的稀缺性，异种瓣膜脱细胞化的概念目前正在研究中。两个当前的概念，引导组织再生和组织工程进行了批判性的讨论。虽然引导组织再生在动物实验中显示出有希望的结果，但没有科学证据表明所获得的结果可以转移到人类身上。利用脱细胞异种心脏瓣膜进行组织工程的方法具有巨大的潜力，然而，在潜在的临床应用之前，许多问题需要研究和澄清。
Due to human valve (allograft) scarcity, the concept of decellularization of xenogeneic valves is currently pursued. The two current concepts of guided tissue regeneration and tissue engineering are critically discussed. While guided tissue regeneration shows promising results in animal experiments, there is no scientific evidence that the obtained results might be transferred to the human. The approach of tissue engineering using decellularized xenogeneic heart valves bears enormous potential, however, numerous issues need to be studied and clarified prior potential clinical application.