Regulation of seasonal reproduction by hypothalamic activation of thyroid hormone.

Regulation of seasonal reproduction by hypothalamic activation of thyroid hormone.
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DOI:
10.3389/fendo.2014.00012
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发表时间:
2014
影响因子:
5.2
通讯作者:
Yoshimura T
Yoshimura T
中科院分区:
医学2区
文献类型:
--
作者:
Shinomiya A;Shimmura T;Nishiwaki-Ohkawa T;Yoshimura T

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Organisms living outside the tropics measure the changes in the length of the day to adapt to seasonal changes in the environment. Animals that breed during spring and summer are called long-day breeders, while those that breed during fall are called short-day breeders. Although the influence of thyroid hormone in the regulation of seasonal reproduction has been known for several decades, its precise mechanism remained unknown. Recent studies revealed that the activation of thyroid hormone within the mediobasal hypothalamus plays a key role in this phenomenon. This localized activation of the thyroid hormone is controlled by thyrotropin (thyroid-stimulating hormone) secreted from the pars tuberalis of the pituitary gland. Although seasonal reproduction is a rate-limiting factor in animal production, genes involved in photoperiodic signal transduction pathway could emerge as potential targets to facilitate domestication.
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