Prognostic significance of vascular endothelial growth factor expression in adult patients with acute myeloid leukemia: a meta-analysis
Prognostic significance of vascular endothelial growth factor expression in adult patients with acute myeloid leukemia: a meta-analysis
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DOI：
10.3109/10428194.2012.748907
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发表时间：
2013-07-01
影响因子：
2.6
通讯作者：
Cen, Hong
中科院分区：
文献类型：
--
作者：
Guo, Baoping;Liu, Yan;Cen, Hong
血管生成标记物的预后意义仍存在争议。许多研究表明，血管内皮生长因子 (VEGF) 或血管内皮生长因子受体 (VEGFR) 过度表达与成人急性髓系白血病 (AML) 患者较差的生存率相关，但一些研究表明生存率较高。为了研究成人 AML 中 VEGF 过度表达的预后意义，我们对已发表的研究进行了荟萃分析，这些研究根据 VEGF 表达状态提供了生存信息。合并风险比 (HR) 表明 VEGF 过度表达对成年 AML 患者的生存影响较差。无事件生存期 (EFS) 的综合风险比为 1.40，总生存期的汇总 HR 为 1.54。通过酶联免疫吸附测定，AML 的汇总 HR 为 1.92，通过免疫组织化学测定，AML 的汇总 HR 为 1.67。这些发现表明 VEGF 过度表达对 AML 患者的预后产生不利影响。在成人 AML 患者的靶向治疗中，VEGF 可能成为一个有用的预后因素。
The prognostic significance of angiogenic markers remains controversial. Many studies have suggested that vascular endothelial growth factor (VEGF) or vascular endothelial growth factor receptor (VEGFR) overexpression correlates with poorer survival in adult patients with acute myeloid leukemia (AML), but some studies suggest a greater probability of survival. To investigate the prognostic significance of VEGF overexpression in adult AML, we performed a meta-analysis of the published studies that provided survival information according to VEGF expression status. Pooled hazard ratios (HRs) indicated that VEGF overexpression had a poor impact on the survival of adult patients with AML. The combined hazard ratio for event-free survival (EFS) was 1.40 and summary HR for overall survival was 1.54. The pooled HR was 1.92 in AML by enzyme-linked immunosorbent assay and 1.67 in AML by immunohistochemistry. These findings indicate that VEGF overexpression has an adverse impact on prognosis for patients with AML. VEGF may become a useful prognostic factor in the context of targeted therapy for patients with adult AML.