Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers.
Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers.
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DOI：
10.1016/j.envint.2016.03.013
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发表时间：
2016-07
影响因子：
11.8
通讯作者：
Brugge D
中科院分区：
文献类型：
--
作者：
Lane KJ;Levy JI;Scammell MK;Peters JL;Patton AP;Reisner E;Lowe L;Zamore W;Durant JL;Brugge D
长期暴露于细颗粒物与心血管疾病和全身炎症反应有关；然而，关于长期暴露于超细颗粒物（UFP, <100 nm）的影响的证据有限。我们采用横断面研究设计来检查长期暴露于高速公路附近的UFP与全身炎症和凝血的关系。我们分析了408名年龄在40-91岁之间的人的血液样本，这些人生活在马萨诸塞州波士顿及其附近的三个高速公路附近和三个城市背景区。我们对每个区域的颗粒数浓度（PNC）进行了移动监测，并利用这些数据开发和验证了高分辨率的时空（每小时，20 m） PNC回归模型。这些模型与参与者的时间-活动数据相关联，以确定个人时间-活动调整（TAA）年平均PNC暴露。采用多变量回归模型和分层来评估TAA-PNC与外周血中高敏c反应蛋白（hsCRP）、白细胞介素-6 （IL-6）、肿瘤坏死因子α受体II （TNFRII）和纤维蛋白原的关系。在调整了年龄、性别、受教育程度、体重指数、吸烟和种族/民族等因素后，TAA-PNC的四分位数范围（10,000颗粒/cm3）增加与hsCRP增加14.0% （95% CI: -4.6%, 36.2%）、IL-6增加8.9% （95% CI: - 0.4%, 10.9%）和TNFRII增加5.1% （95% CI: - 0.4%, 10.9%）呈正相关。种族/民族分层显示，TAA-PNC对所有三种炎症标志物有更大的影响，并且在非西班牙裔白人中与hsCRP和TNFRII显著相关，但在东亚参与者中没有。纤维蛋白原与TAA-PNC无显著负相关。我们的研究结果表明，年平均公路附近TAA- PNC与CVD风险的亚临床炎症标志物之间存在关联。
Long-term exposure to fine particulate matter has been linked to cardiovascular disease and systemic inflammatory responses; however, evidence is limited regarding the effects of long-term exposure to ultrafine particulate matter (UFP, <100 nm). We used a cross-sectional study design to examine the association of long-term exposure to near-highway UFP with measures of systemic inflammation and coagulation. We analyzed blood samples from 408 individuals aged 40–91 years living in three near-highway and three urban background areas in and near Boston, Massachusetts. We conducted mobile monitoring of particle number concentration (PNC) in each area, and used the data to develop and validate highly resolved spatiotemporal (hourly, 20 m) PNC regression models. These models were linked with participant time-activity data to determine individual time-activity adjusted (TAA) annual average PNC exposures. Multivariable regression modeling and stratification were used to assess the association between TAA-PNC and single peripheral blood measures of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor-necrosis factor alpha receptor II (TNFRII) and fibrinogen. After adjusting for age, sex, education, body mass index, smoking and race/ethnicity, an interquartile-range (10,000 particles/cm3) increase in TAA-PNC had a positive non-significant association with a 14.0% (95% CI : -4.6%, 36.2%) increase in hsCRP, an 8.9% (95% CI: −0.4%, 10.9%) increase in IL-6, and a 5.1% (95% CI: −0.4%, 10.9%) increase in TNFRII. Stratification by race/ethnicity revealed that TAA-PNC had larger effect estimates for all three inflammatory markers and was significantly associated with hsCRP and TNFRII in white non-Hispanic, but not East Asian participants. Fibrinogen had a negative non-significant association with TAA-PNC. Our findings suggest an association between annual average near-highway TAA- PNC and subclinical inflammatory markers of CVD risk.