Differences in Thallium-201 uptake in reperfused and nonreperfused myocardial infarction.
Differences in Thallium-201 uptake in reperfused and nonreperfused myocardial infarction.
复制标题
再灌注和非再灌注心肌梗死中铊 201 摄取的差异。
DOI：
10.1161/01.res.53.3.414
复制
发表时间：
1983
影响因子：
20.1
通讯作者：
Bulkley,BH
中科院分区：
文献类型：
--
作者：
Melin,JA;Becker,LC;Bulkley,BH
在再灌注和非再灌注实验性心肌梗死中，研究了血流和细胞活力在确定初始心肌铊摄取中的各自重要性。开胸犬接受70分钟（n = 3）或5小时持续时间（n = 5）的永久冠状动脉闭塞，或3小时临时闭塞后再流（n = 14）。铊摄取静脉注射后10分钟直接比较放射性微球在离体心脏的心肌样品。氯化三苯基四唑染色用于区分坏死和存活样本，并通过电子显微镜进行确认。在非再灌注梗死，铊摄取发生，尽管坏死，和铊摄取和局部心肌血流量之间的密切相关性。在再灌注梗死，铊摄取再次发生，但相对于坏死心肌的流量减少，在较小程度上，在再灌注可行的地区。然而，由于高水平的回流，实际的铊摄取往往超过50%的正常再灌注坏死区。这项研究表明，铊摄取的存在是一个不可靠的指标心肌损伤和再灌注坏死组织可能有显着高水平的铊摄取。
The respective importance of flow and cellular viability in determining initial myocardial thallium uptake was studied in reperfused and nonreperfused experimental myocardial infarction. Open-chest dogs were subjected to permanent coronary artery occlusion of 70-minute (n = 3) or 5-hour duration (n = 5), or to a 3-hour temporary occlusion followed by reflow (n = 14). Thallium uptake 10 minutes after intravenous injection was compared directly with radioactive microspheres in myocardial samples from excised hearts. Triphenyl tetrazolium chloride staining was used to differentiate necrotic and viable samples with confirmation by electron microscopy. In nonreperfused infarcts, thallium uptake occurred despite necrosis, and a close correlation was found between thallium uptake and regional myocardial blood flow. In reperfused infarcts, thallium uptake again occurred, but was reduced relative to flow in necrotic myocardium and, to a lesser extent, in reperfused viable areas. However, because of the high levels of reflow, actual thallium uptake was often more than 50% of normal in reperfused necrotic regions. This study demonstrates that the presence of thallium uptake is an unreliable indicator of myocardial injury and that reperfused necrotic tissue may have remarkably high levels of thallium uptake.