Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients
Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients
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DOI：
10.1016/j.jcv.2014.02.005
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发表时间：
2014-06-01
影响因子：
8.8
通讯作者：
Delhaes, Laurence
中科院分区：
文献类型：
--
作者：
Goffard, Anne;Lambert, Valerie;Delhaes, Laurence
背景资料：很少有研究表明，呼吸道病毒在囊性纤维化（CF）恶化的潜在作用，但其真实的影响可能被低估。方法：六十四痰标本收集46例成人患者包括在研究中：33个样本收集在CF恶化，和31在稳定期。提取后，检测核酸中是否存在呼吸道病毒。当检测到鼻病毒（HRV）时，对5 ' UTR和VP 4/2区进行测序，并进行遗传学分析。结果：25%的标本检出病毒感染。HRV病毒是最常检测到的，其次是冠状病毒。只有心率变异性检测与CF肺加重的发生显著相关（p
Background: Few studies have suggested the potential role of respiratory viruses in cystic fibrosis (CF) exacerbation, but their real impact is probably underestimated.Method: Sixty-four sputum samples collected from 46 adult patients were included in the study: 33 samples were collected during exacerbation of CF, and 31 during the stable phase. After extraction, nucleic acids were tested for the presence of respiratory viruses. When rhinovirus (HRV) was detected, the 5 ' UTR and VP4/2 regions were sequenced, and phylogenetically analyzed. The characteristics of patients in exacerbation and stable phase were compared.Results: Viruses were found in 25% of samples. The HRV viruses were the most frequently detected followed by coronaviruses. Only the HRV detection was significantly associated with the occurrence of CF pulmonary exacerbation (p