SIRT3 is correlated with the malignancy of non-small cell lung cancer
SIRT3 is correlated with the malignancy of non-small cell lung cancer
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DOI：
10.3892/ijo.2017.3868
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发表时间：
2017-03-01
影响因子：
5.2
通讯作者：
Han, Yong
中科院分区：
文献类型：
--
作者：
Xiong, Yanlu;Wang, Mingxing;Han, Yong
线粒体脱乙酰酶SIRT3作为癌基因在某些癌症的发生和发展中起着关键作用。然而，在其他情况下，它具有抗癌作用。其相互冲突的作用可能是由于它根据不同癌症中活性细胞内信号传导途径的背景而修饰不同的关键蛋白质。因此，SIRT3是预防和治疗癌症的新靶点。在本研究中，我们探讨SIRT3在非小细胞肺癌（NSCLC）中的功能，旨在阐明其潜在的机制。我们首先通过实时PCR、蛋白质印迹和免疫组织化学在来自70例具有相关临床病理数据的NSCLC组织和邻近正常组织的配对样本的组织微阵列上确定SIRT3表达水平。SIRT3蛋白和mRNA在NSCLC组织中的表达水平明显高于正常组织（P
The mitochondrial deacetylase SIRT3 plays a pivotal role in the initiation and the progression of certain cancers acting as an oncogene. However, in others it acts anti-oncogenically. Its conflicting action is possibly due to the different key proteins it modifies depending on the context of active intracellular signaling pathways in different cancers. SIRT3 is thus a novel target for preventing and treating cancer. In the present study, we explored the function of SIRT3 in non-small cell lung cancer (NSCLC) with the aim of elucidating the underlying mechanisms. We first determined the SIRT3 expression levels by real-time PCR, western blotting and immunohistochemistry on tissue microarrays of paired samples of NSCLC tissue and adjacent normal tissue from 70 patients with associated clinicopathological data. Levels of SIRT3 protein and mRNA were significantly increased in NSCLC tissue, compared with normal tissue (P