Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes
Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes
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DOI：
10.2337/diacare.26.9.2622
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发表时间：
2003-09-01
期刊：
影响因子：
16.2
通讯作者：
Inukai, T
中科院分区：
文献类型：
--
作者：
Aso, Y;Okumura, K;Inukai, T
目的：我们比较了2型糖尿病患者和年龄匹配的对照组的血浆白细胞介素（IL）-18浓度，并研究了血浆IL-18是否与血浆总同型半胱氨酸（tHcy）浓度或颈动脉内膜中层壁厚度（IMT）相关，IMT是动脉粥样硬化的早期标志物，研究设计和方法-我们测量了103名2型糖尿病患者和45名年龄匹配的对照受试者的血浆IL-18。同时检测患者血浆tHcy和血清超敏C反应蛋白（hs-CRP）。结果-糖尿病患者血浆IL-18显著高于对照组（203 +/-153vs. 118 +/-37pg/ml，P < 0.001）。高IL-18定义为等于或超过对照受试者血浆IL-18的平均值± 2 SD（192 pg/ml）。高IL-18患者颈动脉IMT较正常IL-18患者更大。高IL-18的糖尿病患者的颈动脉斑块比IL-18正常的患者多。血浆tHcy浓度在高IL-18患者中显著高于正常IL-18患者。单变量和多变量分析显示tHcy和IL-18之间存在强的独立相关性。血浆IL-18也与血清hs-CRP.CONCLUSIONS呈正相关-在2型糖尿病患者中，血浆IL-18浓度高于非糖尿病受试者。血浆IL-18是血浆tHcy的独立决定因素，其与动脉粥样硬化颈动脉壁增厚独立相关。
OBJECTIVE - We compared plasma interleukin (lL)-18 concentrations in patients with type 2 diabetes with those in age-matched control subjects and investigated whether plasma IL-18 was associated with plasma total homocysteine (tHcy) concentration or carotid intimal-media wall thickness (IMT), an early marker of atherosclerosis, in these patients.RESEARCH DESIGN AND METHODS - We measured plasma IL-18 in 103 type 2 diabetic patients and 45 age-matched control subjects. We also measured patients' plasma tHcy and serum high-sensitivity C-reactive protein (hs-CRP). IMT was evaluated for both common carotid arteries.RESULTS - Plasma IL-18 was significantly higher in diabetic patients than in control subjects (203 +/- 153 vs. 118 +/- 37 pg/ml, P < 0.001). High IL-18 was defined as equaling or exceeding the mean + 2 SD of plasma IL-18 in control subjects (192 pg/ml). Patients with high IL-18 showed a greater carotid IMT than those with normal IL-18. Carotid plaques were more numerous in diabetic patients with high IL-18 than in those with normal IL-18. Plasma tHcy concentrations were significantly higher in patients with high IL-18 than in those with normal IL-18. Univariate and multivariate analyses showed a strong independent association between tHcy and IL-18. Plasma IL-18 also correlated positively with serum hs-CRP.CONCLUSIONS - inpatients with type 2 diabetes, plasma IL-18 concentrations are greater than in nondiabetic subjects. Plasma IL-18 is an independent determinant of plasma tHcy, which is linked independently with atherosclerotic carotid wall thickening.