Second primary tumors following tobacco dependence treatments among head and neck cancer patients
Second primary tumors following tobacco dependence treatments among head and neck cancer patients
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DOI：
10.1097/coc.0b013e318059adfc
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发表时间：
2007-10-01
影响因子：
2.6
通讯作者：
Hurt, Richard D.
中科院分区：
文献类型：
--
作者：
Garces, Yolanda I.;Schroeder, Darrell R.;Hurt, Richard D.
目的：目的：统计1988 ~ 2001年烟草依赖咨询后，头颈部癌患者和尼古丁依赖中心（NDC）人群中原发癌的累积发病率。方法：采用1：1配对设计和分层考克斯比例风险模型。一般NDC群体对照在年龄、性别和NDC咨询（类型和日期）上与H&N癌症患者匹配。研究人群包括101例H&N癌症患者（66例男性，35例女性），平均（SD）年龄为58.7（10.1）years.Results：基线人口统计学和随访时间组间相似。然而，H&N癌症患者每天吸烟量高于对照组（P < 0.003）。对于H&N癌症患者，从最初的H&N癌症诊断到NDC咨询的中位时间为7个月（范围，0-292个月）。在NDC咨询后，27例H&N癌症患者发生了32例SPT;而在对照组中，12例患者发生了12例其他癌症（P = 0.013）。在非烟草相关癌症的发展方面没有差异（P = 0.273）。然而，H&N癌症患者更容易患上烟草相关癌症（P = 0.01）。此外，有一种趋势，即继续使用烟草的H&N癌症患者比保持戒烟的患者更容易患上与烟草相关的癌症（P = 0. 05）。结论：这些发现证实，H&N癌症患者更容易患上与烟草有关的癌症。此外，这些研究结果表明，停止使用烟草的H&N癌症患者能够减少与烟草相关的SPT的发展。
Objectives: To estimate the cumulative percentage of second primary tumors (SPTs) in head and neck (H&N) cancer patients and primary cancers in general Nicotine Dependence Center (NDC) population controls following tobacco dependence consultation seen between 1988 and 2001.Methods: A 1:1 matched pair design and a stratified Cox proportional hazard model were used. General NDC population controls were matched on age, gender, and NDC consult (type and date) to the H&N cancer patients. The study population included 101 H&N cancer patients (66 male, 35 female) with mean (SD) age of 58.7 (10.1) years.Results: Baseline demographics and length of follow-up were similar between groups. However, H&N cancer patients smoked more cigarettes per day than controls ( P < 0.003). For H&N cancer patients, the median time from initial H&N cancer diagnosis to NDC consult was 7 months (range, 0-292 months). Following the NDC consult, 27 H&N cancer patients developed 32 SPTs; whereas among the controls, 12 patients developed 12 other cancers (P = 0.0 13). There was no difference in the development of non-tobaccorelated cancers (P = 0.273). However, H&N cancer patients were more likely to develop tobacco-related cancers (P = 0.01). Furthermore, there was a trend where the H&N cancer patients who continued to use tobacco were more likely to develop tobaccorelated cancers than those who remained abstinent (P = 0. 10).Conclusions: These findings confirm that H&N cancer patients are more prone to the development of tobacco-related cancers. Further, these findings suggest that H&N cancer patients who stop using tobacco are able to decrease the development of tobacco-related SPTs.