Effects of propyl paraben on the male reproductive system
Effects of propyl paraben on the male reproductive system
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DOI：
10.1016/s0278-6915(02)00204-1
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发表时间：
2002-12-01
影响因子：
4.3
通讯作者：
Oishi, S
中科院分区：
文献类型：
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作者：
Oishi, S
对羟基苯甲酸酯是一种对羟基苯甲酸酯类化合物，广泛用作食品、化妆品、洗漱用品和药品的防腐剂。体外雌激素受体试验和体内子宫营养试验表明，这些化合物具有较弱的雌激素活性。在先前的一项研究中，本作者证明，断奶后的哺乳动物暴露于对羟基苯甲酸丁酯会对睾丸激素的分泌和雄性生殖系统的功能产生不利影响。本研究表明，对羟基苯甲酸丙酯对激素分泌和男性生殖功能也有不利影响。对羟基苯甲酸丙酯给药于3周龄大鼠，分为4组，每组8只，剂量分别为0.00、0.01、0.10和1.00%，配合AIN93G改良日粮。4周后，处死大鼠，测定睾丸、附睾、前列腺、精囊和包皮腺的重量。在任何研究组中，对羟基苯甲酸丙酯对器官重量没有治疗相关的影响。附睾尾精子储备和浓度呈剂量依赖性降低，且剂量在0.10%及以上时差异显著。对羟基苯甲酸丙酯各组睾丸的日精子产量及其效率均显著降低。血清睾酮浓度呈剂量依赖性下降，最高剂量组下降明显。观察到这种影响的接触水平与欧共体和日本对羟基苯甲酸酯的可接受每日摄入量上限（10毫克/公斤体重/天）相同。(C) 2002 Elsevier Science Ltd.版权所有。
Parabens are p-hydroxybenzoic acid ester compounds widely used as preservatives in foods, cosmetics, toiletries and pharmaceuticals. These compounds exert a weak estrogenic activity as determined by in vitro estrogen receptor assay and in vivo uterotrophic assay. In a previous study, it was demonstrated by the present author that exposure of post-weaning mammals to butyl paraben adversely affects the secretion of testosterone and the function of the male reproductive system. In the present study, it is shown that propyl paraben also adversely affects the hormonal secretion and the male reproductive functions. Propyl paraben was administered to 3-week-old rats which were divided into four groups of eight animals each, at doses of 0.00, 0.01, 0.10 and 1.00% with the AIN93G modified diet. At the end of 4 weeks, the rats were sacrificed by decapitation and the weights of testes, epididymides, prostates, seminal vesicles and preputial glands were determined. There were no treatment-related effects of propyl paraben on the organ weights in any of the study groups. The cauda epididymal sperm reserves and concentrations decreased in a dose-dependent manner and the difference was significant at dose of 0.10% and above. Daily sperm production and its efficiency in the testis of all groups receiving propyl paraben significantly decreased. The serum testosterone concentration decreased in a dose-dependent manner and the decrease was significant in the group that received the highest dose. The exposure level at which this effect was observed is the same as the upper-limit acceptable daily intake (10 mg/kg body weight/day) of parabens in the European Community and Japan. (C) 2002 Elsevier Science Ltd. All rights reserved.