The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors
The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors
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DOI：
10.1016/j.cell.2005.07.026
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发表时间：
2005-09-09
期刊：
影响因子：
64.5
通讯作者：
Desplan, C
中科院分区：
文献类型：
--
作者：
Mikeladze-Dvali, T;Wernet, MF;Desplan, C
果蝇的色觉依赖于两种对颜色敏感的光感受器R7和R8之间的比较。两种类型的小眼，其中R7和R8含有不同的视紫红质随机分布在视网膜上，并出现歧视短（p-子集）或长波长（y-子集）。在R7中进行p和y命运之间的选择，然后R7指示R8遵循相应的命运，从而导致R7和R8中表达的视紫红质之间的紧密偶联。在这里，我们表明，疣，编码大肿瘤抑制（Lats）和熔化编码PH结构域蛋白，发挥相反的作用，在定义yR 8或pR 8的命运。通过在转录水平上的拮抗性相互作用，它们形成了一个确保R8对单一命运的稳健承诺而不允许模糊性的β环。这代表了控制细胞增殖（疣及其伴侣河马和萨尔瓦多）和细胞生长（melted）的基因在有丝分裂后发挥了意想不到的作用。
Color vision in Drosophila relies on the comparison between two color-sensitive photoreceptors, R7 and R8. Two types of ommatidia in which R7 and R8 contain different rhodopsins are distributed stochastically in the retina and appear to discriminate short (p-subset) or long wavelengths (y-subset). The choice between p and y fates is made in R7, which then instructs R8 to follow the corresponding fate, thus leading to a tight coupling between rhodopsins expressed in R7 and R8. Here, we show that warts, encoding large tumor suppressor (Lats) and melted encoding a PH-domain protein, play opposite roles in defining the yR8 or pR8 fates. By interacting antagonistically at the transcriptional level, they form a bistable loop that insures a robust commitment of R8 to a single fate, without allowing ambiguity. This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted).