The Use of Functional Near-Infrared Spectroscopy to Differentiate Alcohol-Related Neurodevelopmental Impairment
The Use of Functional Near-Infrared Spectroscopy to Differentiate Alcohol-Related Neurodevelopmental Impairment
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DOI：
10.1080/87565641.2019.1567734
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发表时间：
2019-01-01
影响因子：
1.5
通讯作者：
Coles, Claire D.
中科院分区：
文献类型：
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作者：
Barrett, Catherine E.;Kable, Julie A.;Coles, Claire D.
使用功能性近红外光谱（fNIRS）测量前额叶皮层（PFC）中的氧合（HBO）和脱氧血红蛋白（HBR）水平，以确定认知抑制任务期间PFC活动是否将产前酒精暴露（PAE，n =26）的儿童与典型发育对照组（n =19）和其他神经行为问题的对照组（n =14）区分开来。尽管有证据表明，在非抑制条件下，PFC活性相对于对照组增加，但PAE组的儿童在抑制条件下，PFC HBO相对于其他两组减少，HBR相对于其他两组增加，这表明PFC活性减少，但耗氧量增加，没有足够的氧气替代。
Oxygenated (HBO) and deoxygenated hemoglobin (HBR) levels in the prefrontal cortex (PFC) were measured using functional near-infrared spectroscopy (fNIRS) to determine if PFC activity during a cognitive inhibition task distinguishes children with prenatal alcohol exposure (PAE, n =26) from both typically developing controls (n =19) and a contrast group of children with other neurobehavioral problems (n =14). Despite showing evidence of increased PFC activity in the non-inhibitory condition relative to controls, children in the PAE group displayed reduced PFC HBO and increased HBR relative to both other groups in the inhibitory condition, suggesting reduced PFC activity but increased oxygen consumption without sufficient oxygen replacement.