Initial clinical experience with microwave breast imaging in women with normal mammography
Initial clinical experience with microwave breast imaging in women with normal mammography
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DOI：
10.1016/j.acra.2006.10.016
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发表时间：
2007-02-01
影响因子：
4.8
通讯作者：
Paulsen, Keith D.
中科院分区：
文献类型：
--
作者：
Meaney, Paul M.;Fanning, Margaret W.;Paulsen, Keith D.
理由和目标。我们已经开发了用于实验性乳房成像的微波断层扫描系统。材料和方法。在本文中，我们说明了一种基于体内测量数据来优化天线阵列的耦合液体的策略。我们提出了代表性的幻影实验，以说明成像系统在预期在临床上遇到的介电特性范围内恢复准确的属性分布的能力。为了证明临床可行性并评估体内正常乳腺癌的微波特性，我们根据乳房成像报告和数据系统（BI-RADS 1）（bi-Rads 1）进行了43位患有乳房X线X摄影负阴性女性的微波乳房检查的初步经验。临床结果显示在整个乳房平均微波特性中具有高度的双侧对称性。微波特性的焦点评估与通过磁共振图像图像相关性在选定病例中验证的乳腺组织组成相关。具体而言，全胸平均水平和局部微波特性都随着放射线摄影密度的增加而增加，其中后者表现出更为实质性的上升。这些发现支持了我们的假设，即乳房中的水含量变化在决定整体介电性能分布方面起着影响力，并表明乳房中的微波性能比以前认为的基于在文献中报道的过体性质测量值的先前认为。
Rationale and Objectives. We have developed a microwave tomography system for experimental breast imaging.Materials and Methods. In this article, we illustrate a strategy for optimizing the coupling liquid for the antenna array based on in vivo measurement data. We present representative phantom experiments to illustrate the imaging system's ability to recover accurate property distributions over the range of dielectric properties expected to be encountered clinically. To demonstrate clinical feasibility and assess the microwave properties of the normal breast in vivo, we summarize our initial experience with microwave breast exams of 43 women with negative mammography according to the Breast Imaging Reporting and Data System (BI-RADS 1).Results. The clinical results show a high degree of bilateral symmetry in the whole breast average microwave properties. Focal assessments of microwave properties are associated with breast tissue composition evaluated through radiographic density categorization verified through magnetic resonance image correlation in selected cases. Specifically, both whole-breast average and local microwave properties increase with increasing radiographic density, in which the latter exhibits a more substantial rise.Conclusion. These findings support our hypothesis that water content variations in the breast play an influential role in dictating the overall dielectric property distributions and indicate that the microwave properties in the breast are more heterogeneous than previously believed based on ex vivo property measurements reported in the literature.