Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells
Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells
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DOI：
10.1271/bbb.110800
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发表时间：
2012-03-01
影响因子：
1.6
通讯作者：
Tsuji, Akihiko
中科院分区：
文献类型：
--
作者：
Yuasa, Keizo;Tada, Kaori;Tsuji, Akihiko
尽管一些多甲氧基黄酮具有多种重要的生物学特性，包括神经保护、抗癌和抗炎等，但对酸橘丁（一种来自酸橘的多甲氧基黄酮）的研究却很少。在这项研究中，我们发现sudachitin通过抑制脂多糖刺激的巨噬细胞中诱导型一氧化氮合酶的表达来抑制一氧化氮的产生，这表明sudachitin具有抗炎作用。
Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.