The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism
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DOI：
10.1016/s0167-0115(01)00236-1
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发表时间：
2001-06-15
影响因子：
--
通讯作者：
Fujimiya, M
中科院分区：
文献类型：
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作者：
Tatemoto, K;Takayama, K;Fujimiya, M
爱帕琳是人孤儿受体APJ的内源性配体。我们在脂肪细胞、胃粘膜和肝脏枯否细胞中检测到apelin样免疫反应性。我们还检测到apelin样免疫反应性定位在各种器官的小动脉内皮细胞。此外，发现在麻醉大鼠中以10 nmol/kg的剂量施用爱帕琳-12、爱帕琳-13和爱帕琳-36后，平均动脉压分别降低了26 +/-5、11 +/-4和5 +/-4 mm Hg。在一氧化氮（NO）合酶抑制剂的存在下，apelin-12对血压的影响被取消。此外，给予爱帕琳-12。(10 nmol/kg）使血浆亚硝酸盐/硝酸盐浓度从21.4 +/-1.6 μ M的基础水平暂时升高到27.0 +/-1.5 μ M。因此，爱帕琳肽可以通过一氧化氮依赖性机制降低血压。(C)2001 Elsevier Science B.V.保留所有权利。
Apelin is an endogenous ligand of the human orphan receptor APJ. We detected apelin-like immunoreactivity in the adipocytes, gastric mucosa, and Kupffer cells in the liver. We also detected apelin-like immunoreactivity localized within the endothelia of small arteries in various organs. Further, it was found that mean arterial pressure after the administration of apelin-12, apelin-13, and apelin-36 at a dose of 10 nmol/kg in anaesthetized rats was reduced by 26 +/- 5, 11 +/- 4, and 5 +/- 4 mm Hg, respectively. In the presence of a nitric oxide (NO) synthase inhibitor, the effect of apelin-12 on blood pressure was abolished. Furthermore, the administration of apelin-12. (10 nmol/kg) in rats produced a transitory elevation of the plasma nitrite/nitrate concentration from a basal level of 21.4 +/- 1.6 to 27.0 +/- 1.5 muM Thus, apelin may lower blood pressure via a nitric oxide-dependent mechanism. (C) 2001 Elsevier Science B.V. All rights reserved.