Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window
Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window
复制标题
第二透明窗口中活体近红外荧光成像技术的挑战和机遇
DOI：
10.1021/acsnano.8b07536
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发表时间：
2018-10-01
期刊：
影响因子：
17.1
通讯作者：
Wang, Qiangbin
中科院分区：
文献类型：
--
作者：
Li, Chunyan;Wang, Qiangbin
近十年来，在近红外第二透明窗口（NIR-II, 1000-1700 nm）中，纳米探针和成像光学技术得到了快速发展。这些方法由于其对组织的深度穿透和图像的高保真度，在生物医学应用中具有很大的前景。然而，这些技术在生物医学研究和转化医学中的应用将需要解决一些问题。从这个角度来看，我们研究了活体NIR-II荧光成像技术的技术挑战，并讨论了这种尖端技术在未来的发展方向。
The past decade has witnessed rapid technological development on nanoscale probes and imaging optics in the second near-infrared transparency window (NIR-II, 1000-1700 nm). These methods hold great promise for biomedical applications due to their deep penetration through tissues and high fidelity of images. However, applications of these techniques in biomedical research and translational medicine will require a number of issues to be addressed. In this Perspective, we examine the technical challenges for intravital NIR-II fluorescence imaging technology and discuss where the development of this cutting-edge technique fits in the future.