Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1
Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1
复制标题
Secoisolariciresinol diglucoside 通过 DAF-16 和 HSF-1 延缓衰老相关疾病的进展并延长秀丽隐杆线虫的寿命
DOI：
10.1155/2020/1293935
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发表时间：
2020-07-15
影响因子：
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通讯作者：
Wu, Gui-Sheng
中科院分区：
文献类型：
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作者：
Lu, Min;Tan, Lin;Wu, Gui-Sheng
Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed, sunflower seeds, and sesame seeds. Among the beneficial pharmacological activities of SDG on health, many are age related, such as anticancer, antidiabetes, antioxidant, and neuroprotective effects. Thus, we investigated if SDG had an effect on antiaging inCaenorhabditis elegans(C. elegans). Our results showed that SDG could extend the lifespan ofC. elegansby up to 22.0%, delay age-related decline of body movement, reduce the lethality of heat and oxidative stress, alleviate dopamine neurodegeneration induced by 6-hydroxydopamine (6-OHDA), and decrease the toxicity of A beta protein inC. elegans. SDG could increase the expression of the downstream genes of DAF-16, DAF-12, NHR-80, and HSF-1 at mRNA level. SDG could not extend the lifespan of mutants from genesdaf-16,hsf-1,nhr-80,daf-12,glp-1,eat-2, andaak-2. The above results suggested that SDG might enhance the stress resistance, delay the progression of aging-related diseases, and extend the lifespan ofC. elegansvia DAF-16 and HSF-1.
