Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease
Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease
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DOI：
10.1007/s11906-006-0010-2
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发表时间：
2006-05-01
影响因子：
5.6
通讯作者：
Mehta, Jawahar L.
中科院分区：
文献类型：
--
作者：
Chen, Jiawei;Mehta, Jawahar L.
高脂血症和高血压常见于冠状动脉疾病患者。已经提出低密度脂蛋白，特别是其氧化形式（ox-LDL）和肾素-血管紧张素系统（RAS）激活之间的相互作用是动脉粥样硬化发生的主要决定因素。Ox-LDL在血管中的积累增强了RAS成分的表达和激活；另一方面，RAS的激活刺激LDL在血管中的积累并氧化为ox-LDL。ox-LDL和RAS单独激活可诱导氧化应激和炎症级联反应，而它们的联合则具有协同作用。ox-LDL/高脂血症与RAS激活之间的串扰概念已在实验动物中得到证实。临床试验还表明，阻断高脂血症和RAS可能对高血压和/或有动脉粥样硬化表现的患者的预后有协同有益的作用。这一概念需要在大型临床研究中进一步评估。
Hyperlipidemia and hypertension are frequently observed in patients with coronary artery disease. It has been proposed that an interaction between low-density lipoprotein, especially its oxidized form (ox-LDL), and renin-angiotensin system (RAS) activation is a major determinant of atherogenesis. Ox-LDL accumulation in the blood vessels enhances the expression and activation of RAS components; on the other hand, activation of RAS stimulates the accumulation of LDL and its oxidation into ox-LDL in the blood vessels. Individually ox-LDL and RAS activation induce oxidative stress and inflammatory cascade, whereas their combination exerts a synergistic effect. This concept of cross-talk between ox-LDL/hyperlipidemia and, RAS activation has been proven in laboratory animals. Clinical trials also suggest that blockade of hyperlipidemia and RAS may have a synergistic salutary effect on the outcome of patients with, hypertension and/or manifestations of atherosclerosis. This concept needs to be evaluated further in large clinical studies.