DNA damage hypersensitivity in cells lacking BRCA2:: a review of in vitro and in vivo data
DNA damage hypersensitivity in cells lacking BRCA2:: a review of in vitro and in vivo data
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DOI：
10.1042/bst0330715
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发表时间：
2005-08-01
影响因子：
3.9
通讯作者：
Clarke, AR
中科院分区：
文献类型：
--
作者：
Hay, T;Clarke, AR
自从肿瘤抑制因子 BRCA2（由乳腺癌易感基因 2 编码）被发现以来，缺乏全功能蛋白的细胞一直被发现对各种 DNA 损伤剂（尤其是那些交联 DNA 的药物）表现出更高的敏感性。在这篇简短的综述中，我们将汇总这些发现，并根据我们最近在小鼠小肠中的体内数据进行讨论，这表明删除缺乏 Brco2 的细胞对于避免在该组织中形成潜在的致瘤性克隆是必要的，该系统在具有 BRCA2 种系突变的人类乳腺中可能不太有效。
Since the discovery of the tumour suppressor BRCA2 (encoded by breast-cancer susceptibility gene 2), cells lacking the fully functional protein have consistently been found to show increased sensitivity to a variety of DNA-damaging agents, particularly those that cross-link DNA. in this short review, we will bring together these findings and discuss them in the light of our recent in vivo data in the mouse small intestine, which suggests that deletion of cells lacking Brco2 is necessary to avoid the development of potentially tumorigenic clones in this tissue, a system that may be less effective in the mammary glands of humans with germline mutations in BRCA2.