Analysis of Exhaled Breath for Disease Detection
Analysis of Exhaled Breath for Disease Detection
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DOI：
10.1146/annurev-anchem-071213-020043
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Risby, Terence
中科院分区：
文献类型：
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作者：
Amann, Anton;Miekisch, Wolfram;Risby, Terence
呼吸分析是一个年轻的研究领域，具有巨大的临床潜力。由于这种兴趣，研究人员开发了新的分析技术，除了使用气相色谱-质谱法的传统中心实验室方法外，还可以实时分析呼出气的呼吸分辨率。呼吸测试是基于内源性产生的挥发物，摄入前体的代谢物，肠道或气道中细菌产生的代谢物，或环境暴露后出现的挥发物。呼出气的组成可能包含对患有哮喘、肾脏和肝脏疾病、肺癌、慢性阻塞性肺病、炎性肺病或代谢紊乱的患者有价值的信息。此外，氧化应激状态可以通过脂质过氧化的挥发性产物来监测。酶活性的测量提供了在个性化医疗中重要的表型信息，而呼吸测量提供了对人类干扰的洞察，并且可以被解释为不良结果途径的临床前信号。
Breath analysis is a young field of research with great clinical potential. As a result of this interest, researchers have developed new analytical techniques that permit real-time analysis of exhaled breath with breath-to-breath resolution in addition to the conventional central laboratory methods using gas chromatography-mass spectrometry. Breath tests are based on endogenously produced volatiles, metabolites of ingested precursors, metabolites produced by bacteria in the gut or the airways, or volatiles appearing after environmental exposure. The composition of exhaled breath may contain valuable information for patients presenting with asthma, renal and liver diseases, lung cancer, chronic obstructive pulmonary disease, inflammatory lung disease, or metabolic disorders. In addition, oxidative stress status may be monitored via volatile products of lipid peroxidation. Measurement of enzyme activity provides phenotypic information important in personalized medicine, whereas breath measurements provide insight into perturbations of the human exposome and can be interpreted as preclinical signals of adverse outcome pathways.