Total IgE plasma levels vary according to gender and age in Brazilian patients with allergic rhinitis
Total IgE plasma levels vary according to gender and age in Brazilian patients with allergic rhinitis
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DOI：
10.6061/clinics/2014(11)06
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发表时间：
2014-11-01
期刊：
影响因子：
2.7
通讯作者：
Mattos, Luiz Carlos de
中科院分区：
文献类型：
--
作者：
Couto, Thaís Amarante Peres de Paula;Falsarella, Nelson;Mattos, Luiz Carlos de
目的：变应性鼻炎是一种影响上呼吸道并引起鼻黏膜炎症的疾病，它是由环境变应原致敏后产生的IgE抗体介导的。以前的报告表明，这种疾病对男性的影响比女性更大。本研究的目的是验证变应性鼻炎患者血浆总IgE水平是否存在性别差异。方法：入选171例成人变应性鼻炎患者(男55例，女116例)。用商用试剂盒测定血浆总IgE水平，以140IU/m L为参考值。结果：变应性鼻炎患者的平均年龄为38.4±19.0岁，性别间差异有统计学意义(男性：32.2±17.8岁；女性：41.4±18.9岁；P=0.0027)。男性平均血浆总IgE水平(413.0+/-143.0 IU/m L)高于女性(147.9+/-98.0IU/m L)(P
OBJECTIVE: Allergic rhinitis is a disease that affects the upper airways and causes inflammation of the nasal mucosa and it is mediated by IgE antibodies produced after sensitization to environmental allergens. Previous reports have indicated that this disease affects males more often than females. The objective of this study was to verify whether total IgE plasma levels vary between genders in patients suffering from allergic rhinitis.METHODS: A total of 171 adult patients suffering from allergic rhinitis (55 males and 116 females) were enrolled. Total IgE plasma levels were determined using commercial kits, with 140 IU/mL considered as a reference value. The mean total IgE plasma levels were compared according to gender and age.RESULTS: The mean age of the overall patient group with allergic rhinitis was 38.4 +/- 19.0 years and a significant difference in age was observed between genders (males: 32.2 +/- 17.8 years; females: 41.4 +/- 18.9 years; p = 0.0027). Additionally, the mean total IgE plasma levels were higher in males (413.0 +/- 143.0 IU/mL) than in females (147.9 +/- 98.0 IU/mL) (p