Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton

Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton
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DOI:
10.1039/b415346d
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发表时间:
2005-02-28
影响因子:
4.9
通讯作者:
Hoshino, T
Hoshino, T
中科院分区:
化学2区
文献类型:
--
作者:
Nakano, C;Okamura, T;Hoshino, T

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结核分枝杆菌Rv 3377 c基因的克隆及在大肠杆菌中的功能性表达表明,该基因编码的二萜环化酶可产生(+)-5(6),13-卤螺二烯-15-醇,该酶以香叶基香叶基二磷酸为内源底物。
The cloning and functional expression of Mycobacterium tuberculosis Rv3377c in Escherichia coli revealed that this gene encodes the diterpene cyclase for producing (+)-5(6),13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as the intrinsic substrate.