MEASUREMENT OF LEAN BODY-MASS AND TOTAL-BODY FAT USING DUAL PHOTON-ABSORPTIOMETRY
MEASUREMENT OF LEAN BODY-MASS AND TOTAL-BODY FAT USING DUAL PHOTON-ABSORPTIOMETRY
复制标题
DOI：
10.1016/0026-0495(86)90101-0
复制
发表时间：
1986-01-01
影响因子：
9.8
通讯作者：
CHRISTIANSEN, C
中科院分区：
文献类型：
--
作者：
GOTFREDSEN, A;JENSEN, J;CHRISTIANSEN, C
本文介绍了一种双光子吸收法（DPA）测量瘦体重（LBM）和体脂（FAT）的方法。采用全身直线扫描，放射源为1 Ci 153 Gd。用牛肌肉、猪油和人骨组成的肢体模型，在体外评估了估计瘦肉率的可靠性。瘦肉率测定的精密度和准确度分别为1.5%和1.9%。测量软组织总质量（TMST）的体内准确度误差约为1.4%，因此LBM的总体准确度误差约为2.5%。对5名健康受试者重复测量的瘦肉百分比和LBM（kg）的体内精密度分别为2.5%和2.2%。LBM和FAT的其他估计，即，将根据Boddy等人的计算和皮褶厚度测量（三头肌和肩胛下）与100名健康受试者的DPA测量进行比较。在通过DPA测定的FAT或FAT%与（1）根据Boddy等人的公式计算的FAT或FAT%和（2）皮褶厚度之间发现了高度相关性。然而，Boddy等人的FAT和FAT%与皮褶厚度之间的相关性是中等的。Boddy等人的LBM之间的相关性非常显著（r = 0.96，SEE = 4.4%）。我们的结论是，LBM和脂肪测量使用DPA的精度和准确性误差，是相称的可靠估计的总体身体组成。该方法将适用于横断面内分泌学研究，以及监测疾病和治疗期间身体成分的变化。
We describe a method for measuring the lean body mass (LBM) and total body fat (FAT) by dual photon absorptiometry (DPA). A total body rectilinear scan was employed with a radiation source of 1 Ci 153Gd. The reliability of estimating the lean percent was assessed in vitro using limb phantoms consisting of ox muscle, lard, and human bone. The precision and accuracy in vitro of the lean percent determination were 1.5% and 1.9%, respectively. The accuracy error in vivo of measuring the total mass of soft tissues (TMST) was approximately 1.4%, thus yielding an overall accuracy error of the LBM of about 2.5%. The precision in vivo of the lean percent and the LBM in kg of duplicate measurements on five healthy subjects was 2.5% and 2.2%, respectively. Other estimates of the LBM and FAT, i.e., the calculation according to Boddy et al and the skinfold thickness measurement (triceps and subscapular), were compared to the DPA measurement in 100 healthy subjects. High correlations were found between the FAT or FAT% by DPA versus (1) the FAT or FAT% calculated according to the formulae of Boddy et al, and (2) the skinfold thickness. The correlations between the FAT and FAT% by Boddy et al and the skinfold thickness were, however, moderate. The correlation between LBM by Boddy et al was highly significant (r = 0.96, SEE = 4.4%). We conclude that LBM and FAT measurements using DPA have precision and accuracy errors that are commensurate with a reliable estimation of the gross body composition. The method will be suitable in cross-sectional endocrinological studies, as well as for monitoring changes in body composition during disease and treatment.