Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract.
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract.
复制标题
DOI：
10.1038/s41579-021-00542-7
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Schultz-Cherry S
中科院分区：
文献类型：
--
作者：
Flerlage T;Boyd DF;Meliopoulos V;Thomas PG;Schultz-Cherry S
流感病毒引起呼吸道感染的年度流行和偶尔大流行，在人类中产生广泛的临床疾病严重程度。新型β冠状病毒严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）于2019年12月出现，此后引发了大流行。病毒和宿主因素决定了病毒引起的肺损伤的程度和严重程度。宿主对病毒感染的反应是病毒清除所必需的，但可能是有害的，并导致严重的疾病表型。类似地，组织修复机制是从疾病严重程度的感染中恢复所必需的;然而，失调的修复反应可能导致慢性肺功能障碍。了解病毒性下呼吸道感染后的免疫病理学和组织修复机制可能会拓宽治疗选择。在这篇综述中，我们讨论了发病机制，严重的临床表型的宿主反应的贡献，并强调流感病毒感染后的早期和晚期上皮修复机制，其中每一个都有很好的特点。虽然我们仍在了解SARS-CoV-2及其在人类中的疾病表现，但在整个综述中，我们在广泛了解流感病毒的背景下讨论了对SARS-CoV-2的了解，强调了呼吸道病毒之间的相似性和差异。在这篇综述中，Schultz-Cherry、托马斯及其同事讨论了流感病毒和严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）在人类呼吸道中的发病机制、宿主对严重疾病的反应、感染后的上皮修复机制以及流感病毒和SARS-CoV-2感染的当前和潜在未来疗法。
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract infections that produce a wide spectrum of clinical disease severity in humans. The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has since caused a pandemic. Both viral and host factors determine the extent and severity of virus-induced lung damage. The host’s response to viral infection is necessary for viral clearance but may be deleterious and contribute to severe disease phenotypes. Similarly, tissue repair mechanisms are required for recovery from infection across the spectrum of disease severity; however, dysregulated repair responses may lead to chronic lung dysfunction. Understanding of the mechanisms of immunopathology and tissue repair following viral lower respiratory tract infection may broaden treatment options. In this Review, we discuss the pathogenesis, the contribution of the host response to severe clinical phenotypes and highlight early and late epithelial repair mechanisms following influenza virus infection, each of which has been well characterized. Although we are still learning about SARS-CoV-2 and its disease manifestations in humans, throughout the Review we discuss what is known about SARS-CoV-2 in the context of this broad knowledge of influenza virus, highlighting the similarities and differences between the respiratory viruses. In this Review, Schultz-Cherry, Thomas and colleagues discuss the pathogenesis of influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human respiratory tract, the contribution of the host response to severe disease, epithelial repair mechanisms following infection, and current and potential future therapies for influenza virus and SARS-CoV-2 infections.
登录
查看更多内容
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
64.5
作者：
Aid M;Busman-Sahay K;Vidal SJ;Maliga Z;Bondoc S;Starke C;Terry M;Jacobson CA;Wrijil L;Ducat S;Brook OR;Miller AD;Porto M;Pellegrini KL;Pino M;Hoang TN;Chandrashekar A;Patel S;Stephenson K;Bosinger SE;Andersen H;Lewis MG;Hecht JL;Sorger PK;Martinot AJ;Estes JD;Barouch DH
通讯作者：
Barouch DH
影响因子：
56.9
作者：
Broggi, Achille;Ghosh, Sreya;Zanoni, Ivan
通讯作者：
Zanoni, Ivan
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
168.9
作者：
Bradley, Benjamin T.;Maioli, Heather;Marshall, Desiree A.
通讯作者：
Marshall, Desiree A.