Pulmonary embolism in pregnancy
Pulmonary embolism in pregnancy
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DOI：
10.1016/s0140-6736(09)60996-x
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发表时间：
2010-02-06
期刊：
影响因子：
168.9
通讯作者：
Rodger, Marc
中科院分区：
文献类型：
--
作者：
Bourjeily, Ghada;Paidas, Michael;Rodger, Marc
肺栓塞（PE）是发达国家孕产妇死亡的主要原因。妊娠期PE的死亡率可能与针对正确人群进行预防，确保诊断可疑并进行充分调查，以及及时和尽可能最好地治疗这种疾病的挑战有关。妊娠是Virchow三联征的一个例子：高凝状态、静脉淤滞和血管损伤;这些因素共同导致静脉血栓栓塞的发生率增加。这种疾病通常在孕妇中被怀疑，因为怀孕的一些生理变化模仿其体征和症状。尽管存在与诊断检测相关的胎儿致畸性和致瘤性以及药物治疗的潜在不良反应，但PE的准确诊断和及时的治疗干预至关重要。适当的预防措施应与并发症的风险相权衡，并根据风险分层提供。
Pulmonary embolism (PE) is the leading cause of maternal mortality in the developed world. Mortality from PE in pregnancy might be related to challenges in targeting the right population for prevention, ensuring that diagnosis is suspected and adequately investigated, and initiating timely and best possible treatment of this disease. Pregnancy is an example of Virchow's triad: hypercoagulability, venous stasis, and vascular damage; together these factors lead to an increased incidence of venous thromboembolism. This disorder is often suspected in pregnant women because some of the physiological changes of pregnancy mimic its signs and symptoms. Despite concerns for fetal teratogenicity and oncogenicity associated with diagnostic testing, and potential adverse effects of pharmacological treatment, an accurate diagnosis of PE and a timely therapeutic intervention are crucial. Appropriate prophylaxis should be weighed against the risk of complications and offered according to risk stratification.