Regio-controlled iodoaminocyclization reaction of an ambident nucleophile mediated by LiAl(Ot-Bu)(4)
Regio-controlled iodoaminocyclization reaction of an ambident nucleophile mediated by LiAl(Ot-Bu)(4)
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DOI：
10.1016/s0040-4039(96)02405-7
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发表时间：
1997-01-27
影响因子：
1.8
通讯作者：
Taguchi, T
中科院分区：
文献类型：
--
作者：
Kitagawa, O;Fujita, M;Taguchi, T
本文报道了碘介导的不饱和氨基甲酸酯、脲和酰胺的环化反应的新方法。本反应通过LiAl（Ot-Bu）（4）对两亲核试剂的区域控制而以良好的产率进行，并且区域控制（N-攻击vs O-攻击）也被发现显著地受所使用的添加剂的影响。(C)1997年，爱思唯尔科学有限公司保留所有权利。
A new and general method of iodine-mediated cyclization reactions of unsaturated carbamates, ureas and amides which gives N-cyclized products as a single regio-isomer was achieved. The present reaction proceeds in good yield through regio-control of an ambident nucleophile by LiAl(Ot-Bu)(4), and the regio-control (N-attack vs O-attack) was also found to be remarkably affected by the additive employed. (C) 1997, Elsevier Science Ltd. All rights reserved.