Mandibular bone effects of botulinum toxin injections in masticatory muscles in adult
Mandibular bone effects of botulinum toxin injections in masticatory muscles in adult
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DOI：
10.1016/j.oooo.2019.03.007
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发表时间：
2020-02-01
影响因子：
2.9
通讯作者：
Chappard, Daniel
中科院分区：
文献类型：
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作者：
Kahn, Alexis;Kun-Darbois, Jean-Daniel;Chappard, Daniel
目标。肉毒杆菌毒素(BTX)被注射到咀嚼肌肉中来治疗各种疾病。动物研究表明，将BTX注射到咀嚼肌后，下颌骨的髁突和牙槽骨区域会发生骨丢失。本研究的目的是调查接受咀嚼肌肉注射BTX的患者下颌骨的变化。研究设计。12名成年患者接受了BTX咀嚼肌肉注射的研究。分别于注射前和注射后12个月行锥束CT检查。用游程法对CBCT图像进行纹理分析，对下颌骨的髁突和牙槽区进行分析。测量髁突皮质厚度，并对下颌骨进行三维分析。6例未接受BTX注射的患者作为对照。在髁突和牙槽骨中发现游程长度参数(灰度级不均匀)增加。右侧髁突前部皮质明显变薄。三维分析显示，髁状突骨和二腹窝处有明显改变。下颌角无明显变化。这项研究确定了接受BTX咀嚼肌注射的成年患者的下颌骨变化。
Objective. Botulinum toxin (BTX) is injected into masticatory muscles to treat various conditions. Animal studies have demonstrated bone loss at the condylar and alveolar regions of the mandible after BTX injection into masticatory muscles. The aim of the present study was to investigate mandibular bone changes in patients who received BTX injections in masticatory muscles.Study Design. Twelve adult patients who received BTX injections into masticatory muscles were included in this study. Cone beam computed tomography (CBCT) was performed before and 12 months after the injection. The condylar and alveolar regions of the mandible were analyzed by using texture analysis of the CBCT images with the run length method. Condylar cortical thickness was measured, and 3-dimensional analysis of the mandible was also performed. Six patients who did not receive BTX injections were used as controls.Results. A run length parameter (gray level nonuniformity) was found to be increased in condylar and alveolar bones. A significant cortical thinning was found at the anterior portion of the right condyle. Three-dimensional analysis showed significant changes in the condylar bone and at the digastric fossa. No changes in mandibular angles were found.Conclusions. This study identified mandibular bone changes in adult patients who received BTX injection into masticatory muscles.