Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility
Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility
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DOI：
10.1007/s10856-010-4048-y
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发表时间：
2010-06-01
影响因子：
3.7
通讯作者：
Lee, Byong-Taek
中科院分区：
文献类型：
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作者：
Nguyen Thi Hiep;Lee, Byong-Taek
在本研究中，将不同比例的PLGA加入到PLGA/PCL溶液中，制备了电纺PLGA/PCL共混物。用于制备电纺纤维毡的PLGA/PCL比例反映在FT-IR(傅立叶变换红外光谱)数据中。四甲基偶氮唑盐实验结果表明，电纺共聚物的生物相容性随着PLGA含量的增加而增加。用扫描电子显微镜观察成纤维细胞在电纺垫上的细胞黏附和增殖情况。此外，我们还发现随着PLGA浓度的增加，电纺膜的力学性能发生变化，PLGA/PCL电纺纤维膜的生物相容性增强。
In this study, an electro-spun co-polymer PLGA/PCL blend was fabricated using various percentages of PLGA in the blend PLGA/PCL solutions. The PLGA/PCL ratios used to fabricate the electrospun fibrous mats were reflected in the FT-IR (Fourier Transform Infrared Spectroscopy) data. Experimental results from the MTT assay showed that the biocompatibility of the electro-spun co-polymer increased at increasing percentages of PLGA. In vitro cells adhesion and proliferation of fibroblast cells on electro-spun mats were characterized by SEM morphology. In addition, we found that increasing PLGA concentrations affected the mechanical properties of electro-spun membranes and increased the biocompatibility of PLGA/PCL electro-spun fibrous mats.