Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age
Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age
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DOI：
10.1016/j.jaac.2012.12.011
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发表时间：
2013-03-01
影响因子：
13.3
通讯作者：
Sigman, Marian
中科院分区：
文献类型：
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作者：
Messinger, Daniel;Young, Gregory S.;Sigman, Marian
目的：自闭症谱系障碍（ASD）患者的一级亲属患ASD相关特征的风险增加。由于对这些特征的早期表达知之甚少，本研究描述了ASD儿童3岁高风险（HR）兄弟姐妹的非ASD结局。方法：两组无ASD的儿童参与：507名HR兄弟姐妹和324名低风险（LR）对照组（无已知的ASD亲属）。儿童在平均8个月大时入组，并在3岁时评估结果。结果的措施是自闭症诊断观察计划（ADOS）校准的严重程度评分，和马伦言语和非言语发育商（DQ）。结果如下：在3年时，没有ASD结局的HR兄弟姐妹表现出比LR对照组更高的平均ADOS严重程度评分和更低的语言和非语言DQ。HR同胞在以ADOS严重程度升高和/或低至低平均DQ为特征的潜在类别中的代表性过高（21% HR vs 7% LR）。其余的HR兄弟姐妹没有ASD的结果（79%）属于类，在这些类中，他们没有区别代表LR兄弟姐妹。结论：从所有分析中删除了先前确定的18.7%的HR兄弟姐妹ASD结果，HR兄弟姐妹仍然表现出比LR儿童更高的ASD严重程度平均水平和更低的发育功能水平。然而，潜在的类成员的五分之四的HR兄弟姐妹没有显着不同的LR控制对象。五分之一的HR兄弟姐妹属于ASD严重程度较高和/或发育功能水平较低的类别。这种经验得出的表征的早期出现的模式的困难，在少数3岁的HR兄弟姐妹表明，发展监测和早期干预这些孩子的重要性。J. Am. Acad.儿童青少年。精神病学; 2013;52（3）：300-308。
Objective: First-degree relatives of persons with an autism spectrum disorder (ASD) are at increased risk for ASD-related characteristics. As little is known about the early expression of these characteristics, this study characterizes the non-ASD outcomes of 3-year-old high-risk (HR) siblings of children with ASD. Method: Two groups of children without ASD participated: 507 HR siblings and 324 low-risk (LR) control subjects (no known relatives with ASD). Children were enrolled at a mean age of 8 months, and outcomes were assessed at 3 years. Outcome measures were Autism Diagnostic Observation Schedule (ADOS) calibrated severity scores, and Mullen Verbal and Non-Verbal Developmental Quotients (DQ). Results: At 3 years, HR siblings without an ASD outcome exhibited higher mean ADOS severity scores and lower verbal and non-verbal DQs than LR controls. HR siblings were over-represented (21% HR versus 7% LR) in latent classes characterized by elevated ADOS severity and/or low to low-average DQs. The remaining HR siblings without ASD outcomes (79%) belonged to classes in which they were not differentially represented with respect to LR siblings. Conclusions: Having removed a previously identified 18.7% of HR siblings with ASD outcomes from all analyses, HR siblings nevertheless exhibited higher mean levels of ASD severity and lower levels of developmental functioning than LR children. However, the latent class membership of four-fifths of the HR siblings was not significantly different from that of LR control subjects. One-fifth of HR siblings belonged to classes characterized by higher ASD severity and/or lower levels of developmental functioning. This empirically derived characterization of an early-emerging pattern of difficulties in a minority of 3-year-old HR siblings suggests the importance of developmental surveillance and early intervention for these children. J. Am. Acad. Child Adolesc. Psychiatry; 2013;52(3):300-308.