Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure
Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure
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DOI：
10.1017/s1355617710000901
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发表时间：
2010-11-01
影响因子：
2.6
通讯作者：
Spurr, Kathleen F.
中科院分区：
文献类型：
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作者：
Lau, Esther Yuet Ying;Eskes, Gail A.;Spurr, Kathleen F.
阻塞性睡眠呼吸暂停 (OSA) 的特点是睡眠期间呼吸紊乱和低氧血症、白天嗜睡以及认知和情绪变化。一个重要的问题是持续气道正压通气 (CPAP) 治疗后认知缺陷的可逆性。在此，我们报告通过注意力和执行功能测试来衡量 CPAP 治疗的结果。对 37 名患有中度至重度 OSA 并符合 CPAP 治疗的个体进行了工作记忆任务、神经心理学测试和过夜研究。多导睡眠图睡眠研究，与 27 名健康对照组相比，CPAP 改善了呼吸紊乱指数最小值和平均氧饱和度 (SpO(2)) 与治疗前的值相比，主观睡眠质量和日间嗜睡评级 就目前的神经认知功能而言，接受 OSA 治疗的个体在基本工作记忆存储功能方面的表现与对照组相当，但在需要中枢执行的工作记忆测试中仍显示出显着降低 OSA 组在复杂注意力、执行功能和精神运动速度的神经心理学测量方面也表现较差虽然 CPAP 是一种有效的 OSA 治疗方法，可改善睡眠期间的呼吸中断和氧饱和度降低以及白天嗜睡，但某些认知缺陷可能更难以治疗 (JINS 2010 16 1077-1088)
Obstructive sleep apnea (OSA) is characterized by disrupted breathing and hypoxemia during sleep daytime sleepiness and changes in cognition and mood One important question is regarding the reversibility of cognitive deficits after treatment with continuous positive airway pressure (CPAP) Here we report the outcomes of CPAP treatment as measured by tests of attention and executive function Thirty-seven individuals with moderate to severe OSA and compliant on CPAP treatment were studied with working memory tasks neuropsychological testing and overnight polysomnographic sleep study and compared to 27 healthy controls CPAP improved the respiratory disturbance index minimum and mean oxygen saturation (SpO(2)) subjective sleep quality and daytime sleepiness ratings compared to pre-treatment values In terms of current neurocognitive function, treated individuals with OSA performed at a comparable level to controls on basic working memory storage functions but still showed a significant reduction on tests of working memory requiring the central executive The OSA group also performed worse on neuropsychological measures of complex attention, executive function, and psychomotor speed While CPAP is an effective treatment for OSA in terms of ameliorating breathing disruption and oxygen desaturation during sleep, as well as daytime sleepiness some cognitive deficits may be more resistant to treatment (JINS 2010 16 1077-1088)