Frequency Selectivity of Persistent Cortical Oscillatory Responses to Auditory Rhythmic Stimulation
Frequency Selectivity of Persistent Cortical Oscillatory Responses to Auditory Rhythmic Stimulation
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DOI：
10.1523/jneurosci.0213-21.2021
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发表时间：
2021-09-22
影响因子：
5.3
通讯作者：
Schon, Daniele
中科院分区：
文献类型：
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作者：
Lerousseau, Jacques Pesnot;Trebuchon, Agnes;Schon, Daniele
已经提出皮层振荡通过神经夹带机制在语音和音乐感知、注意力选择和工作记忆中发挥功能性作用。通常被认为是理所当然的神经夹带的特性之一是，它对正在进行的振荡的调节作用持续时间超过节律性刺激。我们测试了这种现象的存在，通过研究皮层神经振荡期间和之后的旋律刺激的被动感知范式。旋律由嵌入在2.5 Hz流中的类似于60 Hz和类似于80 Hz的音调组成。使用颅内和表面记录在男性和女性的人，我们揭示了持续的振荡活动在高伽玛波段的音调在整个皮层，远远超出听觉区域。相比之下，响应于2.5Hz流，在任何频带中均未观察到持续活动。我们进一步表明，我们的数据被很好地捕获的阻尼谐振子的模型，可以分为三类的神经动力学，具有不同的阻尼特性和本征频率。该模型提供了一个机制和定量解释的频率选择性听觉神经夹带在人类皮层。
Cortical oscillations have been proposed to play a functional role in speech and music perception, attentional selection, and working memory, via the mechanism of neural entrainment. One of the properties of neural entrainment that is often taken for granted is that its modulatory effect on ongoing oscillations outlasts rhythmic stimulation. We tested the existence of this phenomenon by studying cortical neural oscillations during and after presentation of melodic stimuli in a passive perception paradigm. Melodies were composed of similar to 60 and similar to 80 Hz tones embedded in a 2.5 Hz stream. Using intracranial and surface recordings in male and female humans, we reveal persistent oscillatory activity in the high-gamma band in response to the tones throughout the cortex, well beyond auditory regions. By contrast, in response to the 2.5 Hz stream, no persistent activity in any frequency band was observed. We further show that our data are well captured by a model of damped harmonic oscillator and can be classified into three classes of neural dynamics, with distinct damping properties and eigenfrequencies. This model provides a mechanistic and quantitative explanation of the frequency selectivity of auditory neural entrainment in the human cortex.