The poly(A)-limiting element is a conserved cis-acting sequence that regulates poly(A) tail length on nuclear pre-mRNAs
The poly(A)-limiting element is a conserved cis-acting sequence that regulates poly(A) tail length on nuclear pre-mRNAs
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DOI：
10.1073/pnas.96.16.8943
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发表时间：
1999-08-03
影响因子：
11.1
通讯作者：
Schoenberg, DR
中科院分区：
文献类型：
--
作者：
Gu, HD;Das Gupta, J;Schoenberg, DR
大多数脊椎动物mRNA以200+-残基聚（A）尾离开细胞核，并被去腺苷化以在任何给定的mRNA上产生50-200个腺苷残基的异质聚合物。我们以前报道过非洲爪蟾白蛋白mRNA和前体mRNA有一个异常短的、离散的17个残基的poly（A）尾，并表明poly（A）长度的调节独立地由位于末端外显子的两个顺式作用poly（A）限制元件（PLE A和PLE B）控制。本研究试图确定这种调节机制的普遍性。转铁蛋白mRNA也有一个离散的
Most vertebrate mRNAs exit the nucleus with a 200+-residue poly(A) tail and are deadenylated to yield heterogeneous polymers of 50-200 adenosine residues on any given mRNA. We previously reported that Xenopus albumin mRNA and pre-mRNA have an unusually short, discrete 17-residue poly(A) tail and showed that regulation of poly(A) length is controlled independently by two cis-acting poly(A)-limiting elements (PLE A and PLE B) located in the terminal exon. The present study sought to determine the generality of this regulatory mechanism. Transferrin mRNA also has a discrete