Weight of the evidence on the human carcinogenicity of 2,4-D.
Weight of the evidence on the human carcinogenicity of 2,4-D.
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关于2,4-D人类致癌性的证据的重量。
DOI：
10.1289/ehp.9196213
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发表时间：
1991-12
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
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作者：
苯氧基除草剂2，4-二氯苯氧基乙酸(2，4-D)被广泛用于杂草和阔叶植物的除草。我们召集了一个由13名科学家组成的小组，对2，4-D对人类致癌的证据进行权衡。该小组的研究结果基于对有关2，4-D和相关苯氧基除草剂的毒理学和流行病学文献的回顾。毒理学数据没有为预测2，4-D是人类致癌物提供强有力的基础。尽管因果关系还远未确定，但暴露于2，4-D和非霍奇金淋巴瘤之间存在关联的流行病学证据具有启发性，需要进一步研究。几乎没有证据表明2，4-D的使用与软组织肉瘤或霍奇金氏病之间存在关联，也没有证据表明2，4-D的使用与任何其他形式的癌症之间存在关联。专家小组的科学家被要求将2，4-D归类为“已知的”、“可能的”、“可能的”或“不太可能的”致癌物质，或归类为人类的非致癌物质。小组成员中的主要观点是，证据的份量表明，接触2，4-D可能会导致人类癌症，尽管并不是所有的小组成员都认为可能性相同：一人认为可能性很大，倾向于可能性，五人认为可能性很小，倾向于不太可能。两名小组成员认为，2，4-D不太可能导致人类癌症。
The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the human carcinogenicity of 2,4-D. The panel based its findings on a review of the toxicological and epidemiological literature on 2,4-D and related phenoxy herbicides. The toxicological data do not provide a strong basis for predicting that 2,4-D is a human carcinogen. Although a cause–effect relationship is far from being established, the epidemiological evidence for an association between exposure to 2,4-D and non–Hodgkin's lymphoma is suggestive and requires further investigation. There is little evidence of an association between use of 2,4-D and soft-tissue sarcoma or Hodgkin's disease, and no evidence of an association between 2,4-D use and any other form of cancer. Scientists on the panel were asked to categorize 2,4-D as a “known,” “probable,” “possible,” or “unlikely” carcinogen or as a noncarcinogen in humans. The predominant opinion among the panel members was that the weight of the evidence indicates that it is possible that exposure to 2,4-D can cause cancer in humans, although not all of the panelists believed the possibility was equally likely: one thought the possibility was strong, leaning toward probable, and five thought the possibility was remote, leaning toward unlikely. Two panelists believed it unlikely that 2,4-D can cause cancer in humans.