Alanine aminotransferase decreases with age: the Rancho Bernardo Study.
Alanine aminotransferase decreases with age: the Rancho Bernardo Study.
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DOI：
10.1371/journal.pone.0014254
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发表时间：
2010-12-08
期刊：
影响因子：
3.7
通讯作者：
Loomba R
中科院分区：
文献类型：
--
作者：
Dong MH;Bettencourt R;Barrett-Connor E;Loomba R
血清丙氨酸氨基转移酶（ALT）是肝损伤的标志物。2005年美国胃肠病学协会未来趋势委员会报告指出，血清ALT水平随着年龄的增长而保持不变。本研究探讨了美国社区居民血清ALT与年龄之间的关系。一项对2,364名（54%为女性）年龄在30-93岁之间的参与者进行的横断面研究，这些参与者来自1984-87年参加研究诊所访视的Rancho Bernardo研究队列。测量了人口统计学、代谢协变量、ALT、胆红素、γ谷氨酰转移酶（GGT）、白蛋白和肥胖信号生物标志物（瘦素、IL-6、脂联素、胃饥饿素）。根据年龄四分位数将参与者分为四组，并检查多变量调整最小二乘均值（LSM）（趋势p <0.05）。ALT随着年龄的增长而降低，在30-62岁、63-71岁、72-77岁和78-93岁的四分位数人群中，平均ALT水平（IU/L）分别为23、21、20和17（p<0.0001）。在调整性别、饮酒、代谢综合征组分和肥胖生物标志物后，ALT随年龄降低的最小二乘均值趋势和血清ALT升高的患病率随年龄降低的趋势仍然稳健（p值<0.0001），在调整胆红素、GGT和白蛋白后没有实质性变化。男性和女性的ALT水平随年龄增长而下降，与代谢综合征组分、肥胖信号生物标志物和其他常用肝功能检查无关。需要进一步的研究来了解ALT随年龄下降的机制，并建立老年人ALT正常的最佳临界点。
Serum alanine aminotransferase (ALT) is a marker of liver injury. The 2005 American Gastroenterology Association Future Trends Committee report states that serum ALT levels remain constant with age. This study examines the association between serum ALT and age in a community-dwelling cohort in the United States. A cross-sectional study of 2,364 (54% female) participants aged 30–93 years from the Rancho Bernardo Study cohort who attended a research clinic visit in 1984–87. Demographic, metabolic co-variates, ALT, bilirubin, gamma glutamyl transferase (GGT), albumin, and adiposity signaling biomarkers (leptin, IL-6, adiponectin, ghrelin) were measured. Participants were divided into four-groups based upon age quartile, and multivariable-adjusted least squares of means (LSM) were examined (p for trend <0.05). ALT decreased with increasing age, with mean ALT levels (IU/L) of 23, 21, 20, and 17 for those between quartile ages 30–62, 63–71, 72–77, and 78–93 years (p<0.0001). Trends of decreasing LSM ALT with age and the decreasing prevalence of categorically defined elevated serum ALT with age remained robust after adjusting for sex, alcohol use, metabolic syndrome components, and biomarkers of adiposity (p-value <0.0001), and was not materially changed after adjusting for bilirubin, GGT, and albumin. ALT levels decrease with age in both men and women independent of metabolic syndrome components, adiposity signaling biomarkers, and other commonly used liver function tests. Further studies are needed to understand the mechanisms responsible for a decline in ALT with age, and to establish the optimal cut-point of normal ALT in the elderly.
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影响因子：
158.5
作者：
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