Transcranial direct current stimulation for memory enhancement: from clinical research to animal models.
Transcranial direct current stimulation for memory enhancement: from clinical research to animal models.
复制标题
经颅直流电刺激增强记忆：从临床研究到动物模型。
DOI：
10.3389/fnsys.2014.00159
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发表时间：
2014
影响因子：
3
通讯作者：
Van Waes V
中科院分区：
文献类型：
--
作者：
Bennabi D;Pedron S;Haffen E;Monnin J;Peterschmitt Y;Van Waes V
对于认知障碍患者和健康个体来说，对新的大脑增强技术的需求越来越大，以改善心理表现。经颅直流电刺激（tDCS）是一种无创、无痛且易于使用的神经调节技术，尽管其确切的作用模式尚不清楚，但它可以改善人类在各种认知任务上的表现。我们对文献进行了一次小型回顾，首先简要总结了来自评估tDCS疗效的临床试验的越来越多的数据，这些数据专门关注健康人类受试者以及抑郁症、精神分裂症和其他神经系统疾病患者的学习和记忆表现。然后，我们讨论了这些发现的背景下，惊人的少数研究来自动物研究。最后，我们强调了这一领域未来的发展方向和局限性，并强调需要开展转化研究，以更好地了解tDCS如何改善记忆，这是将其用作治疗工具的必要条件。
There is a growing demand for new brain-enhancing technologies to improve mental performance, both for patients with cognitive disorders and for healthy individuals. Transcranial direct current stimulation (tDCS) is a non-invasive, painless, and easy to use neuromodulatory technique that can improve performance on a variety of cognitive tasks in humans despite its exact mode of action remains unclear. We have conducted a mini-review of the literature to first briefly summarize the growing amount of data from clinical trials assessing the efficacy of tDCS, focusing exclusively on learning and memory performances in healthy human subjects and in patients with depression, schizophrenia, and other neurological disorders. We then discuss these findings in the context of the strikingly few studies resulting from animal research. Finally, we highlight future directions and limitations in this field and emphasize the need to develop translational studies to better understand how tDCS improves memory, a necessary condition before it can be used as a therapeutic tool.