SHORT-TERM AND LONG-TERM EFFECTS OF CIGARETTE-SMOKING ON HEART-RATE-VARIABILITY
SHORT-TERM AND LONG-TERM EFFECTS OF CIGARETTE-SMOKING ON HEART-RATE-VARIABILITY
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DOI：
10.1016/0002-9149(90)90030-5
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发表时间：
1990-01-01
影响因子：
2.8
通讯作者：
TAKATA, K
中科院分区：
文献类型：
--
作者：
HAYANO, J;YAMADA, M;TAKATA, K
通过控制呼吸（15次/min）下心率变异性的功率谱分析，研究了吸烟对心脏自主调节的短期和长期影响。对9名无心肺功能障碍的吸烟者进行了短期效果检查。反映呼吸性窦性心律失常的心率谱成分（0.25 Hz），迷走神经心脏控制的定量指标，在吸1支烟后3分钟下降（p = 0.0061）和反映Mayer波窦性心律失常的成分（0.04至0.15 Hz），包括交感神经介导的活动，在10至17分钟后增加（p = 0.0124）。在81名正常受试者中，包括25名不吸烟者、31名中度吸烟者（1 - 24支/天）和25名重度吸烟者（> 25支/天），在过夜戒烟后检查了长期效应。尽管Mayer波分量的幅度不受吸烟状态的影响，但年轻人仰卧位的呼吸分量较小（≤ 0.000000）。30岁）重度吸烟者比年轻的不吸烟者或中度吸烟者（p = 0.0078）。此外，在不吸烟者中观察到这些成分的姿势变化，即呼吸成分减少，Mayer波成分增加，但在重度吸烟者中没有观察到。这些结果表明，吸烟会导致迷走神经心脏控制的急性和短暂的减少，大量吸烟会导致年轻人迷走神经心脏控制的长期减少和自主心脏调节的姿势反应减弱。
The short- and long-term effects of cigarette smoking on autonomic cardiac regulation were investigated by power spectral analysis of heart rate variability under controlled respiration (15/min). The short-term effects were examined in 9 smokers without evidence of cardiopulmonary disorders after an overnight abstinence from smoking. The heart rate spectral component reflecting the respiratory sinus arrhythmia (0.25 Hz), a quantitative index of vagal cardiac control, decreased 3 minutes after smoking 1 cigarette (p = 0.0061) and the component reflecting Mayer wave sinus arrhythmia (0.04 to 0.15 Hz), which includes sympathetically mediated activity, increased after 10 to 17 minutes (p = 0.0124). The long-term effects were examined in 81 normal subjects comprising 25 nonsmokers, 31 moderate (1 to 24 cigarettes/day) smokers and 25 heavy (> 25 cigarettes/day) smokers after an overnight abstinence. Although the magnitude of the Mayer wave component was unaffected by the smoking status, the respiratory component in the supine position was smaller in the young (.ltoreq. 30 years) heavy smokers than in the young nonsmokers or moderate smokers (p = 0.0078). Also, postural changes in the components, a decrease in the respiratory component and an increase in the Mayer wave component with standing, were observed in the nonsmokers but not in the heavy smokers. These results suggest that smoking causes an acute and transient decrease in vagal cardiac control, and that heavy smoking causes long-term reduction in vagal cardiac control in young people and blunted postural responses in autonomic cardiac regulation.